Sequestration of eIF4A by angiomotin: A novel mechanism to restrict global protein synthesis in trophoblast cells
Sign Up to like & getrecommendations! Published in 2020 at "STEM CELLS"
DOI: 10.1002/stem.3305
Abstract: Enrichment of angiomotin (AMOT) in the ectoplacental cone of E7.5 murine placenta prompted our investigation on the role of AMOT in trophoblast differentiation. We show here that AMOT levels increased in mouse placenta during gestation… read more here.
Keywords: eif4a; trophoblast; protein synthesis; amot ... See more keywords
The DEAD-box RNA helicase eIF4A regulates plant development and interacts with the hnRNP LIF2L1 in Physcomitrella patens
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-019-01628-x
Abstract: eIF4A is a RNA-stimulated ATPase and helicase. Besides its key role in regulating cap-dependent translation initiation in eukaryotes, it also performs specific functions in regulating cell cycle progression, plant growth and abiotic stress tolerance. Flowering… read more here.
Keywords: pp3c6 1080v3; physcomitrella patens; eif4a; rna ... See more keywords
Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2019.08.008
Abstract: Rocaglates share a common cyclopenta[b]benzofuran core that inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase, eIF4A. Working as interfacial inhibitors, rocaglates stabilize the association between eIF4A and RNA, which can lead… read more here.
Keywords: potent class; eif4a; rocaglates potent; class eif4a ... See more keywords
The domains of yeast eIF4G, eIF4E and the cap fine-tune eIF4A activities through an intricate network of stimulatory and inhibitory effects
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac437
Abstract: Abstract Translation initiation in eukaryotes starts with the recognition of the mRNA 5′-cap by eIF4F, a hetero-trimeric complex of eIF4E, the cap-binding protein, eIF4A, a DEAD-box helicase, and eIF4G, a scaffold protein. eIF4G comprises eIF4E-… read more here.
Keywords: eif4e cap; stimulatory inhibitory; network stimulatory; cap ... See more keywords
Inhibition of the translation initiation factor eIF4A enhances tumor cell radiosensitivity.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-22-0037
Abstract: A fundamental component of cellular radioresponse is the translational control of gene expression. As a critical regulator of translational control is the eIF4F cap binding complex, we investigated whether eIF4A, the RNA helicase component of… read more here.
Keywords: sds 021; eif4a; cell radiosensitivity; tumor ... See more keywords
eIF4A inhibition: ready for primetime?
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26268
Abstract: Targeted signaling inhibitors have improved treatment options for many cancers, but resistance mediated by redundancies in pathways limits clinical efficacy [1]. Activation of eIF4F, the complex that carries out cap-dependent translation initiation, is a convergence… read more here.
Keywords: initiation; eif4a; target; compound ... See more keywords
Enzymatic and Molecular Characterization of Anti-Leishmania Molecules That Differently Target Leishmania and Mammalian eIF4A Proteins, LieIF4A and eIF4AMus
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27185890
Abstract: Previous investigations of the Leishmania infantum eIF4A-like protein (LieIF4A) as a potential drug target delivered cholestanol derivatives inhibitors. Here, we investigated the mode of action of cholesterol derivatives as a novel scaffold structure of LieIF4A… read more here.
Keywords: leishmania mammalian; anti leishmania; mammalian eif4a; leishmania ... See more keywords