Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity
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DOI: 10.1158/1078-0432.ccr-17-3645
Abstract: Purpose: The DEAD-box RNA helicase eIF4A1 carries out the key enzymatic step of cap-dependent translation initiation and is a well-established target for cancer therapy, but no drug against it has entered evaluation in patients. We… read more here.
Keywords: target based; inhibitor; eif4a1; target ... See more keywords