Identification of Cardiac Glycosides as Novel Inhibitors of eIF4A1-Mediated Translation in Triple-Negative Breast Cancer Cells
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DOI: 10.3390/cancers12082169
Abstract: The eukaryotic translation initiation factor 4F complex (eIF4F) is a potential chemotherapeutic target in triple-negative breast cancer (TNBC). This complex regulates cap-dependent translational initiation and consists of three core proteins: eIF4E, eIF4G, and eIF4A1. In… read more here.
Keywords: eif4a1 mediated; cardiac glycosides; inhibitors eif4a1; translation ... See more keywords