Ribavirin sensitizes nasopharyngeal carcinoma to 5-fluorouracil through suppressing 5-fluorouracil-induced ERK-dependent-eIF4E activation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.053
Abstract: Although overexpression of eukaryotic translation initiation factor 4E (eIF4E) is associated with enhanced growth and poor prognosis in nasopharyngeal carcinoma (NPC), the function of eIF4E in NPC response to chemotherapy has not been revealed. In… read more here.
Keywords: ribavirin; eif4e; fluorouracil; activation ... See more keywords
A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113435
Abstract: The eukaryotic translation initiation factor 4E (eIF4E) is the master regulator of cap-dependent protein synthesis. Overexpression of eIF4E is implicated in diseases such as cancer, where dysregulation of oncogenic protein translation is frequently observed. eIF4E… read more here.
Keywords: inhibitor; eif4e; binding site; internal binding ... See more keywords
Analysis of the interacting partners eIF4F and 3'-CITE required for Melon necrotic spot virus cap-independent translation.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular plant pathology"
DOI: 10.1111/mpp.12422
Abstract: We have shown previously that the translation of Melon necrotic spot virus (MNSV, family Tombusviridae, genus Carmovirus) RNAs is controlled by a 3'-cap-independent translation enhancer (CITE), which is genetically and functionally dependent on the eukaryotic… read more here.
Keywords: eif4e; independent translation; translation; cap independent ... See more keywords
Editing melon eIF4E associates with virus resistance and male sterility
Sign Up to like & getrecommendations! Published in 2022 at "Plant Biotechnology Journal"
DOI: 10.1111/pbi.13885
Abstract: Summary The cap‐binding protein eIF4E, through its interaction with eIF4G, constitutes the core of the eIF4F complex, which plays a key role in the circularization of mRNAs and their subsequent cap‐dependent translation. In addition to… read more here.
Keywords: male sterility; melon; melon eif4e; virus resistance ... See more keywords
Abstract 1624: eIF4E allosteric regulators cause rapid commitment to apoptosis in cancer cells while sparing immune cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1624
Abstract: Advanced or metastatic breast cancers represents a large patient population. Targeted therapies following hormonal or chemotherapeutic approaches offer some benefit. Subsequently, molecular profiling has identified over 100 mutations that render inhibitor resistance, creating challenges for… read more here.
Keywords: cancer; eif4e regulators; breast; immune cells ... See more keywords
Abstract 3722: Exploring the role of eIF4E in cancer cells with targeted protein degradation
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3722
Abstract: Initiation of translation is considered the main rate-limiting step of protein synthesis and requires the recognition of 5’ m7G-cap on mature mRNAs and the formation of eukaryotic translation initiation factor 4F (eIF4F) multi-protein mRNA cap-binding… read more here.
Keywords: targeted protein; cap; protein degradation; cancer ... See more keywords
TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Autism"
DOI: 10.1186/s13229-019-0311-3
Abstract: BackgroundTuberous sclerosis complex (TSC) is a neurodevelopmental disorder with frequent occurrence of epilepsy, autism spectrum disorder (ASD), intellectual disability (ID), and tumors in multiple organs. The aberrant activation of mTORC1 in TSC has led to… read more here.
Keywords: mnk; het; eif4e; het null ... See more keywords
A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.
Sign Up to like & getrecommendations! Published in 2017 at "RNA"
DOI: 10.1261/rna.060137.116
Abstract: The eukaryotic translation initiation factor eIF4E acts in the nuclear export and translation of a subset of mRNAs. Both of these functions contribute to its oncogenic potential. While the biochemical mechanisms that underlie translation are… read more here.
Keywords: export; mrna export; nuclear recycling; eif4e ... See more keywords
Overexpression of p-4EBP1 associates with p-eIF4E and predicts poor prognosis for non-small cell lung cancer patients with resection
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0265465
Abstract: Eukaryotic initiation factor 4E (eIF4E) and its phosphorylated form (p-eIF4E) play a crucial role in the protein synthesis, both are under regulation of eIF4E-binding protein 1 (4EBP1) and mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs). This… read more here.
Keywords: nsclc patients; 4ebp1 eif4e; lung; eif4e ... See more keywords
DrosophilaMe31B is a dual eIF4E-interacting protein.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of molecular biology"
DOI: 10.2139/ssrn.3962716
Abstract: Eukaryotic translation initiation factor 4E (eIF4E) is a key factor involved in different aspects of mRNA metabolism. Drosophila melanogaster genome encodes eight eIF4E isoforms, and the canonical isoform eIF4E-1 is a ubiquitous protein that plays… read more here.
Keywords: interaction; drosophilame31b dual; interacting protein; dual eif4e ... See more keywords
Plant eIF4E isoforms as factors of susceptibility and resistance to potyviruses
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2023.1041868
Abstract: Potyviruses are the largest group of plant-infecting RNA viruses that affect a wide range of crop plants. Plant resistance genes against potyviruses are often recessive and encode translation initiation factors eIF4E. The inability of potyviruses… read more here.
Keywords: plant eif4e; resistance potyviruses; eif4e isoforms; plant ... See more keywords