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   Articles with "eif4e" as a keyword



Ribavirin sensitizes nasopharyngeal carcinoma to 5-fluorouracil through suppressing 5-fluorouracil-induced ERK-dependent-eIF4E activation.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.04.053

Abstract: Although overexpression of eukaryotic translation initiation factor 4E (eIF4E) is associated with enhanced growth and poor prognosis in nasopharyngeal carcinoma (NPC), the function of eIF4E in NPC response to chemotherapy has not been revealed. In… read more here.

Keywords: ribavirin; eif4e; fluorouracil; activation ... See more keywords
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A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders.

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recommendations! Published in 2021 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2021.113435

Abstract: The eukaryotic translation initiation factor 4E (eIF4E) is the master regulator of cap-dependent protein synthesis. Overexpression of eIF4E is implicated in diseases such as cancer, where dysregulation of oncogenic protein translation is frequently observed. eIF4E… read more here.

Keywords: inhibitor; eif4e; binding site; internal binding ... See more keywords

eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production

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recommendations! Published in 2024 at "Nucleus"

DOI: 10.1080/19491034.2024.2360196

Abstract: ABSTRACT The eukaryotic translation initiation factor eIF4E acts as a multifunctional factor that simultaneously influences mRNA processing, export, and translation in many organisms. Its multifactorial effects are derived from its capacity to bind to the… read more here.

Keywords: mrna processing; translation; export translation; eif4e ... See more keywords

eIF4E plays the role of a pathogenic gene in psoriasis, and the inhibition of eIF4E phosphorylation ameliorates psoriasis‐like skin damage

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recommendations! Published in 2024 at "Experimental Dermatology"

DOI: 10.1111/exd.14997

Abstract: Psoriasis is a complex inflammatory skin disease with uncertain pathogenesis. eIF4E (eukaryotic translation initiation factor 4E) and its phosphorylation state p‐eIF4E are highly expressed in psoriatic tissues. However, the role eIF4E played in psoriasis is… read more here.

Keywords: role; phosphorylation; eif4e; eif4e eif4e ... See more keywords

Analysis of the interacting partners eIF4F and 3'-CITE required for Melon necrotic spot virus cap-independent translation.

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recommendations! Published in 2017 at "Molecular plant pathology"

DOI: 10.1111/mpp.12422

Abstract: We have shown previously that the translation of Melon necrotic spot virus (MNSV, family Tombusviridae, genus Carmovirus) RNAs is controlled by a 3'-cap-independent translation enhancer (CITE), which is genetically and functionally dependent on the eukaryotic… read more here.

Keywords: eif4e; independent translation; translation; cap independent ... See more keywords

Editing melon eIF4E associates with virus resistance and male sterility

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recommendations! Published in 2022 at "Plant Biotechnology Journal"

DOI: 10.1111/pbi.13885

Abstract: Summary The cap‐binding protein eIF4E, through its interaction with eIF4G, constitutes the core of the eIF4F complex, which plays a key role in the circularization of mRNAs and their subsequent cap‐dependent translation. In addition to… read more here.

Keywords: male sterility; melon; melon eif4e; virus resistance ... See more keywords

Abstract 1624: eIF4E allosteric regulators cause rapid commitment to apoptosis in cancer cells while sparing immune cells

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-1624

Abstract: Advanced or metastatic breast cancers represents a large patient population. Targeted therapies following hormonal or chemotherapeutic approaches offer some benefit. Subsequently, molecular profiling has identified over 100 mutations that render inhibitor resistance, creating challenges for… read more here.

Keywords: cancer; eif4e regulators; breast; immune cells ... See more keywords

Abstract 3722: Exploring the role of eIF4E in cancer cells with targeted protein degradation

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-3722

Abstract: Initiation of translation is considered the main rate-limiting step of protein synthesis and requires the recognition of 5’ m7G-cap on mature mRNAs and the formation of eukaryotic translation initiation factor 4F (eIF4F) multi-protein mRNA cap-binding… read more here.

Keywords: targeted protein; cap; protein degradation; cancer ... See more keywords

TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling

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recommendations! Published in 2020 at "Molecular Autism"

DOI: 10.1186/s13229-019-0311-3

Abstract: BackgroundTuberous sclerosis complex (TSC) is a neurodevelopmental disorder with frequent occurrence of epilepsy, autism spectrum disorder (ASD), intellectual disability (ID), and tumors in multiple organs. The aberrant activation of mTORC1 in TSC has led to… read more here.

Keywords: mnk; het; eif4e; het null ... See more keywords

A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.

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recommendations! Published in 2017 at "RNA"

DOI: 10.1261/rna.060137.116

Abstract: The eukaryotic translation initiation factor eIF4E acts in the nuclear export and translation of a subset of mRNAs. Both of these functions contribute to its oncogenic potential. While the biochemical mechanisms that underlie translation are… read more here.

Keywords: export; mrna export; nuclear recycling; eif4e ... See more keywords

Overexpression of p-4EBP1 associates with p-eIF4E and predicts poor prognosis for non-small cell lung cancer patients with resection

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recommendations! Published in 2022 at "PLoS ONE"

DOI: 10.1371/journal.pone.0265465

Abstract: Eukaryotic initiation factor 4E (eIF4E) and its phosphorylated form (p-eIF4E) play a crucial role in the protein synthesis, both are under regulation of eIF4E-binding protein 1 (4EBP1) and mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs). This… read more here.

Keywords: nsclc patients; 4ebp1 eif4e; lung; eif4e ... See more keywords