Deciphering the mechanistic effects of eIF4E phosphorylation on mRNA‐cap recognition
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3798
Abstract: The mRNA cap‐binding oncoprotein “eIF4E” is phosphorylated at residue S209 by Mnk kinases, and is closely associated with tumor development and progression. Despite being well‐established, mechanistic details at the molecular level of mRNA recognition by… read more here.
Keywords: recognition; eif4e phosphorylation; mrna cap; cap ... See more keywords
Biological Evaluation of Selected Flavonoids as Inhibitors of MNKs Targeting Acute Myeloid Leukemia.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.0c00516
Abstract: Excessive eIF4E phosphorylation by mitogen-activated protein kinase (MAPK)-interacting kinases 1 and 2 (MNK1 and MNK2; collectively, MNKs) has been associated with oncogenesis. The overexpression of eIF4E in acute myeloid leukemia (AML) is related to cancer… read more here.
Keywords: myeloid leukemia; hispidulin luteolin; eif4e phosphorylation; acute myeloid ... See more keywords
The Androgen Receptor is a negative regulator of eIF4E Phosphorylation at S209: Implications for the use of mTOR inhibitors in advanced prostate cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.233
Abstract: The antiandrogen bicalutamide is widely used in the treatment of advanced prostate cancer (PCa) in many countries, but its effect on castration-resistant PCa (CRPC) is limited. We previously showed that resistance to bicalutamide results from… read more here.
Keywords: resistance; phosphorylation; eif4e phosphorylation; mtor inhibitors ... See more keywords