Interaction of the Influenza A Virus NS1 Protein with the 5'-m7G-mRNA·eIF4E·eIF4G1 Complex.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00019
Abstract: The influenza A virus (IAV) is responsible for seasonal epidemics that result in hundreds of thousands of deaths worldwide annually. The non-structural protein 1 (NS1) of the IAV inflicts various antagonistic processes on the host… read more here.
Keywords: m7g mrna; eif4g1; mrna eif4e; eif4e eif4g1 ... See more keywords
Inhibitors of eIF4G1–eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2120339119
Abstract: Significance eIF4G1 interacts with eIF4E and eIF1 in a mutually exclusive manner. Using a high-throughput drug screen, the eIF1–eIF4G1 inhibitors, named i14G1s, were identified. The i14G1s established the importance of eIF4G1 cooperation with eIF1 in… read more here.
Keywords: response genes; eif4g1; stress response; eif1 ... See more keywords
Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00139-18
Abstract: Translation initiation of most mRNAs involves m7G-cap binding, ribosomal scanning, and AUG selection. Initiation from an m7G-cap-proximal AUG can be bypassed resulting in leaky scanning, except for mRNAs bearing the translation initiator of short 5′… read more here.
Keywords: eif4g1; initiation; translation; eif1 ... See more keywords
Translational Factor eIF4G1 Regulates Glucose Homeostasis and Pancreatic β-Cell Function.
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db20-0057
Abstract: Protein translation is essential for cell physiology, and dysregulation of this process has been linked to aging-related diseases such as type 2 diabetes. Reduced protein level of a requisite scaffolding protein of the initiation complex,… read more here.
Keywords: glucose homeostasis; eif4g1; cell; cell function ... See more keywords
EIF4G1 Is a Potential Prognostic Biomarker of Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12121756
Abstract: Background: Breast cancer (BRCA) is one of the most common cancers in women worldwide and a leading cause of death from malignancy. This study was designed to identify a novel biomarker for prognosticating the survival… read more here.
Keywords: biomarker; expression; breast cancer; eif4g1 ... See more keywords