Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment.
Sign Up to like & getrecommendations! Published in 2021 at "Amino acids"
DOI: 10.1007/s00726-021-03023-6
Abstract: Hypusine [Nε-(4-amino-2-hydroxybutyl)lysine] is a derivative of lysine that is formed post-translationally in the eukaryotic initiation factor 5A (eIF5A). Its occurrence at a single site in one cellular protein defines hypusine synthesis as one of the… read more here.
Keywords: eif5a; hypusine; lysine; post translational ... See more keywords
The pleiotropic roles of eIF5A in cellular life and its therapeutic potential in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20221035
Abstract: Protein synthesis is dysregulated in the majority of cancers and this process therefore provides a good therapeutic target. Many novel anti-cancer agents are directed to target the initiation stage of translation, however, translation elongation also… read more here.
Keywords: pleiotropic roles; roles eif5a; eif5a cellular; eif5a ... See more keywords
EIF5A mediates autophagy via translation of ATG3
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2018.1491213
Abstract: ABSTRACT The core macroautophagy/autophagy machinery consists of a large group of autophagy-related (ATG) proteins, that mediate highly controlled, step-wise execution of this conserved intracellular degradation process. Whereas ATG proteins have been intensely studied in terms… read more here.
Keywords: eif5a; eif5a mediates; atg3; translation ... See more keywords
Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx532
Abstract: Abstract Whereas ribosomes efficiently catalyze peptide bond synthesis by most amino acids, the imino acid proline is a poor substrate for protein synthesis. Previous studies have shown that the translation factor eIF5A and its bacterial… read more here.
Keywords: amino; eif5a; peptide synthesis; requirement ... See more keywords
Eukaryotic Translation Initiation Factor 5A Independently Predicts Poor Prognosis of Cholangiocarcinoma Patients and Regulates the Ferroptosis and Mitochondrial Apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/4250531
Abstract: Cholangiocarcinoma (CCA) is a hepatobiliary carcinoma characterized by the differentiation of bile duct cells, and the patients with CCA often have a poor prognosis. Eukaryotic translation initiation factor 5A (eIF5A) is reported to have multiple… read more here.
Keywords: cca; ferroptosis mitochondrial; mitochondrial apoptosis; poor prognosis ... See more keywords
Eukaryotic translation factor eIF5A contributes to acetic acid tolerance in Saccharomyces cerevisiae via transcriptional factor Ume6p
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology for Biofuels"
DOI: 10.1186/s13068-021-01885-2
Abstract: Background Saccharomyces cerevisiae is well-known as an ideal model system for basic research and important industrial microorganism for biotechnological applications. Acetic acid is an important growth inhibitor that has deleterious effects on both the growth… read more here.
Keywords: eif5a; tolerance; translation factor; acetic acid ... See more keywords