Development of a reliable, sensitive, and convenient assay for the discovery of new eIF5A hypusination inhibitors
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DOI: 10.1371/journal.pone.0308049
Abstract: eIF5A is a translation factor dysregulated in several pathologies such as cancer and diabetes. eIF5A activity depends upon its hypusination, a unique post-translational modification catalyzed by two enzymes: DHPS and DOHH. Only a few molecules… read more here.
Keywords: eif5a hypusination; hyp assay; hypusination inhibitors; convenient ... See more keywords
Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016010012
Abstract: The eukaryotic initiation factor 5A (eIF5A), which is highly conserved throughout evolution, has the unique characteristic of post-translational activation through hypusination. This modification is catalyzed by two enzymatic steps involving deoxyhypusine synthase (DHPS) and deoxyhypusine… read more here.
Keywords: mitochondrial silencing; kidney transplant; eif5a hypusination; gc7 ... See more keywords