Troponin Assessment in Heart Failure With Preserved Ejection Fraction: Time to Get With the Guidelines.
Sign Up to like & getrecommendations! Published in 2017 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2016.4840
Abstract: Over the past 2 decades, heart failure has become the leading cause of cardiovascular morbidity and mortality. Epidemiological studies show that approximately half of the patients diagnosed with heart failure have a normal ejection fraction.1… read more here.
Keywords: troponin; ejection fraction; heart; heart failure ... See more keywords
Efficacy and Safety of Dapagliflozin in Men and Women With Heart Failure With Reduced Ejection Fraction: A Prespecified Analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2021.0379
Abstract: Importance Women may respond differently to certain treatments for heart failure (HF) with reduced ejection fraction (HFrEF) than men. Objective To investigate the efficacy and safety of dapagliflozin compared with placebo in men and women… read more here.
Keywords: ejection fraction; heart; heart failure; men women ... See more keywords
A Simple Score to Identify Increased Risk of Transthyretin Amyloid Cardiomyopathy in Heart Failure With Preserved Ejection Fraction.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2022.1781
Abstract: Importance Transthyretin amyloid cardiomyopathy (ATTR-CM) is a form of heart failure (HF) with preserved ejection fraction (HFpEF). Technetium Tc 99m pyrophosphate scintigraphy (PYP) enables ATTR-CM diagnosis. It is unclear which patients with HFpEF have sufficient… read more here.
Keywords: validation; prevalence; ejection fraction; risk ... See more keywords
Effect of Dapagliflozin on Cause-Specific Mortality in Patients With Heart Failure Across the Spectrum of Ejection Fraction
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Cardiology"
DOI: 10.1001/jamacardio.2022.3736
Abstract: This pooled analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure (DAPA-HF) and Dapagliflozin Evaluation to Improve the Lives of Patients With Preserved Ejection Fraction Heart Failure (DELIVER) trials investigates the effect… read more here.
Keywords: ejection fraction; heart failure; dapagliflozin;
Population-Level Implications of Sodium-Glucose Cotransporter-2 Inhibitors for Heart Failure With Preserved Ejection Fraction in the US.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2022.4348
Abstract: Importance The expansion of sodium-glucose cotransporter-2 (SGLT-2) inhibitor use in patients with heart failure (HF) and left ventricular ejection fraction (LVEF) more than 40% following the EMPEROR-Preserved (Empagliflozin Outcome Trial in Patients with Chronic Heart… read more here.
Keywords: ejection fraction; heart failure; heart;
Safety and Efficacy of Empagliflozin and Diuretic Use in Patients with Heart Failure and Preserved Ejection Fraction: A Post Hoc Analysis of the EMPEROR-Preserved Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2023.1090
Abstract: Importance The diuretic effect of sodium-glucose cotransporter 2 inhibitors may result in interaction with background diuretic therapy in patients with heart failure and preserved ejection fraction (HFpEF). Objective To assess the safety and efficacy of… read more here.
Keywords: ejection fraction; heart failure; emperor preserved; use ... See more keywords
Variability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction
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DOI: 10.1001/jamanetworkopen.2018.1456
Abstract: Key Points Question What is the variability in left ventricular ejection fraction (LVEF) as measured by different cardiac imaging modalities? Findings In this multicenter diagnostic study of 2032 patients with coronary artery disease and LVEF… read more here.
Keywords: patients coronary; ejection fraction; magnetic resonance; variability ... See more keywords
Variability in Reassessment of Left Ventricular Ejection Fraction After Myocardial Infarction in the Acute Myocardial Infarction Quality Assurance Canada Study
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DOI: 10.1001/jamanetworkopen.2021.36830
Abstract: Key Points Question What proportion of patients with left ventricular dysfunction identified during hospitalization for acute myocardial infarction have follow-up assessment of left ventricular ejection fraction (LVEF)? Findings In this cohort study of 501 patients,… read more here.
Keywords: ventricular ejection; left ventricular; infarction; ejection fraction ... See more keywords
Subclinical Risk Factors for Heart Failure With Preserved and Reduced Ejection Fraction Among Black Adults
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.31878
Abstract: Key Points Question Are subclinical measures of cardiovascular and noncardiovascular organ function differentially associated with the incidence of heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF)? Findings In… read more here.
Keywords: ejection fraction; heart failure; ejection;
Optimal Pharmacologic Treatment of Heart Failure With Preserved and Mildly Reduced Ejection Fraction
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.31963
Abstract: Key Points Question What is the optimal drug combination for treatment of heart failure (HF) with preserved ejection fraction (HFpEF) and mildly reduced ejection fraction (HFmrEF)? Findings In this network meta-analysis, 19 randomized clinical trials… read more here.
Keywords: treatment heart; heart failure; failure preserved; ejection ... See more keywords
Detyrosinated α‐tubulin mediates mitochondrial dysfunction and diastolic impairment in heart failure with preserved ejection fraction
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DOI: 10.1002/1873-3468.70119
Abstract: Heart failure with preserved ejection fraction (HFpEF) is characterized by diastolic dysfunction, yet its molecular basis remains unclear. Here, we identified detyrosinated α‐tubulin as a key cause of mitochondrial dysfunction and impaired mitophagy in HFpEF.… read more here.
Keywords: detyrosinated tubulin; failure preserved; dysfunction; ejection fraction ... See more keywords