Evidence That P-glycoprotein Inhibitor (Elacridar)-Loaded Nanocarriers Improve Epidermal Targeting of an Anticancer Drug via Absorptive Cutaneous Transporters Inhibition.
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DOI: 10.1016/j.xphs.2017.09.007
Abstract: Because P-glycoprotein (P-gp) plays an absorptive role in the skin, its pharmacological inhibition represents a strategy to promote cutaneous localization of anticancer agents that serve as its substrates, improving local efficacy while reducing systemic exposure.… read more here.
Keywords: inhibitor elacridar; elacridar; elacridar loaded; drug ... See more keywords