Severe Pulmonary Arterial Hypertension is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency.
Sign Up to like & getrecommendations! Published in 2021 at "Chest"
DOI: 10.1016/j.chest.2021.06.028
Abstract: BACKGROUND Preclinical evidence implicates neutrophil elastase (NE) in PAH pathogenesis, and the NE inhibitor elafin is under early therapeutic investigation. RESEARCH QUESTION Are circulating NE and elafin levels abnormal in PAH and associated with clinical… read more here.
Keywords: severe pulmonary; elafin; pulmonary arterial; neutrophil elastase ... See more keywords
Upregulation of elafin expression in the fallopian tube of ectopic tubal pregnancies compared to the normal tubes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2020.103136
Abstract: BACKGROUND Ectopic pregnancy is one of the most important causes of maternal deaths and fallopian tubes are the location of 95% of ectopic pregnancies. Elafin is a natural antimicrobial molecule that plays an important role… read more here.
Keywords: compared normal; fallopian tube; elafin; expression ... See more keywords
Elafin is related to immune infiltration and could predict the poor prognosis in ovarian cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1088944
Abstract: Background Ovarian cancer (OC) is the most lethal gynecologic malignancy, yet the clinical results for OC patients are still variable. Therefore, we examined how elafin expression affects the patients’ prognoses and immunotherapy responses in OC,… read more here.
Keywords: prognosis; ovarian cancer; expression; mrna expression ... See more keywords
Probiotic Escherichia coli Nissle 1917 Expressing Elafin Protects Against Inflammation and Restores the Gut Microbiota
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.819336
Abstract: Intestinal mucosal inflammation and epithelial barrier dysfunction have been implicated as pathological factors in inflammatory bowel disease (IBD). An emerging area of IBD research focuses on probiotics. The probiotic Escherichia coli Nissle 1917 (EcN) is… read more here.
Keywords: inflammation; ecn elafin; probiotic escherichia; escherichia coli ... See more keywords