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Published in 2023 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmad038
Abstract: Elagolix sodium is a gonadotropin-releasing hormone (GnRH) receptor antagonist that inhibits endogenous GnRH signaling by competitively binding to GnRH receptors in the pituitary gland to treat moderate to severe pain associated with endometriosis. To keep…
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Keywords:
triisopropyl phosphate;
phosphate triisopropyl;
elagolix sodium;
genotoxic impurities ... See more keywords
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1
Published in 2023 at "Journal of AOAC International"
DOI: 10.1093/jaoacint/qsad019
Abstract: BACKGROUND Elagolix is a Gonadotropin-Releasing Hormone (GnRH) modulator and used for pain relief during endometriosis. OBJECTIVE The present research was performed to develop and validate a simple, novel, fast, sensitive and cost-effective LC-MS compatible chromatographic…
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Keywords:
organic impurities;
method quantification;
elagolix sodium;
impurities elagolix ... See more keywords
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2
Published in 2022 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.2139/ssrn.4252205
Abstract: Elagolix sodium (ELS) is a marketed product using to release moderate to severe endometriosis-associated pain. It contains functional groups such as carboxyl group, secondary amino group, 2,4-dioxo pyrimidinyl and several benzyl or benzyl-like position hydrogen…
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Keywords:
hydrogen;
elagolix sodium;
group;
forced degradation ... See more keywords
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Published in 2023 at "Molecules"
DOI: 10.3390/molecules28093861
Abstract: Elagolix sodium salt is the first marketed orally active non-peptide gonadotropin-releasing hormone receptor antagonist (GnRHR-ant) for the management of hormone dependent diseases, such as endometriosis and uterine fibroids. Despite its presence on the market since…
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Keywords:
elagolix sodium;
synthetic intermediates;
salt synthetic;
sodium salt ... See more keywords