Fusobacterium nucleatum exacerbates chronic obstructive pulmonary disease in elastase‐induced emphysematous mice
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13369
Abstract: Exacerbation of chronic obstructive pulmonary disease (COPD) is associated with disease progression and increased mortality. Periodontal disease is a risk factor for exacerbation of COPD, but little is known about the role of periodontopathic bacteria… read more here.
Keywords: elastase; obstructive pulmonary; pulmonary disease; exacerbation ... See more keywords
Structural Diversity and Anticancer Activity of Marine‐Derived Elastase Inhibitors: Key Features and Mechanisms Mediating the Antimetastatic Effects in Invasive Breast Cancer
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DOI: 10.1002/cbic.201700627
Abstract: Three new 3‐amino‐6‐hydroxy‐2‐piperidone (Ahp)‐containing cyclic depsipeptides, named loggerpeptins A–C (1–3), along with molassamide (4), were discovered from a marine cyanobacterium, extending the structural diversity of this prevalent scaffold of cyanobacterial serine protease inhibitors. Molassamide, which… read more here.
Keywords: structural diversity; invasive breast; elastase; breast cancer ... See more keywords
The effects of non-surgical periodontal therapy on neutrophil elastase and elastase alpha-1 proteinase inhibitor levels in GCF in periodontitis patients with or without acute coronary syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-021-03838-3
Abstract: Objective Periodontitis may contribute to vascular damage, resulting in the destabilization of atherosclerotic plaque leading to acute coronary syndrome (ACS). In this study, we explored the effect of non-surgical periodontal treatment (NSPT) on cardiovascular blood… read more here.
Keywords: elastase; group; acute coronary; gcf ... See more keywords
Ellagic Acid Ameliorates Lung Inflammation and Heart Oxidative Stress in Elastase-Induced Emphysema Model in Rat
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01201-4
Abstract: Chronic obstructive pulmonary disease (COPD) is one of the most important factors in the progress of cardiovascular disease (CVD) which is associated with limited airflow and alveolar demolition. The aim of this study is to… read more here.
Keywords: heart; anti oxidant; arterial hypertension; elastase ... See more keywords
Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.115216
Abstract: Neutrophils are one of the most abundant leukocytes in the sites of lesion of inflammatory diseases such as periodontitis and rheumatoid arthritis. These diseases are accompanied by bone loss, which worsens the quality of life… read more here.
Keywords: degradation; osteoclast differentiation; elastase; enhanced osteoclast ... See more keywords
An elastase activity reporter for Electronic Paramagnetic Resonance (EPR) and Overhauser‐enhanced Magnetic Resonance Imaging (OMRI) as a line‐shifting nitroxide
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.08.006
Abstract: Abstract Pulmonary inflammatory diseases are a major burden worldwide. They have in common an influx of neutrophils. Neutrophils secrete unchecked proteases at inflammation sites consequently leading to a protease/inhibitor imbalance. Among these proteases, neutrophil elastase… read more here.
Keywords: resonance; elastase; neutrophil elastase; spectroscopy ... See more keywords
Unravelling protein -organic solvent interaction of organic solvent tolerant elastase from Pseudomonas aeruginosa strain K crystal structure.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.01.056
Abstract: The utilization of organic solvents as reaction media for enzymatic reactions provides numerous industrially attractive advantages. However, an adaptation of enzyme towards organic solvent is unpredictable and not fully understood because of limited information on… read more here.
Keywords: elastase; aeruginosa strain; solvent; solvent tolerant ... See more keywords
Polysaccharides from Kochia scoparia fruits protect mice from lipopolysaccharide-mediated acute lung injury by inhibiting neutrophil elastase
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DOI: 10.1016/j.jff.2017.09.060
Abstract: Abstract Acute lung injury (ALI) is a respiratory disease that is associated with neutrophil activation. Neutrophil elastase released from activated neutrophils has been reported to cause lung tissue damage and contribute to the inflammatory response… read more here.
Keywords: elastase; neutrophil elastase; kochia scoparia; lung injury ... See more keywords
Murine model of invasive pulmonary Aspergillosis: Follow-up of tissue injury, fungal burden and mortality with distinct elastase production strains.
Sign Up to like & getrecommendations! Published in 2019 at "Journal de mycologie medicale"
DOI: 10.1016/j.mycmed.2018.10.003
Abstract: To study invasive pulmonary Aspergillosis (IPA), we depleted neutrophils in mice using the monoclonal antibody anti-Gr-1/Ly-6G. Immunocompetent and neutropenic mice were infected via intratracheal with conidia of Aspergillus fumigatus clinical isolates, characterized as either higher… read more here.
Keywords: pulmonary aspergillosis; tissue injury; elastase; invasive pulmonary ... See more keywords
Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo Biological Evaluation for Acute Lung Injury
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c01583
Abstract: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the most common complications in COVID-19. Elastase has been recognized as an important target to prevent ALI/ARDS in the patient of COVID-19. Cyclotheonellazole A (CTL-A)… read more here.
Keywords: acute lung; elastase inhibitor; elastase; lung injury ... See more keywords
Neutrophil Elastase-Activatable Prodrugs Based on an Alkoxyamine Platform to Deliver Alkyl Radicals Cytotoxic to Tumor Cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00455
Abstract: Current chemotherapies suffer low specificity and sometimes drug resistance. Neutrophil elastase activity in cancer is associated with poor prognosis and metastasis settlement. More generally, tumors harbor various and persistent protease activities unseen in healthy tissues.… read more here.
Keywords: elastase; elastase activatable; neutrophil elastase; alkyl radicals ... See more keywords