LJ-529, a partial peroxisome proliferator-activated receptor gamma (PPARĪ³) agonist and adenosine A3 receptor agonist, ameliorates elastase-induced pulmonary emphysema in mice.
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DOI: 10.1007/s12272-020-01235-0
Abstract: Chronic obstructive pulmonary disease (COPD) is the leading cause of human death worldwide. Currently available therapies for COPD mainly relieve symptoms and preserve lung function, suggesting the need to develop novel therapeutic or preventive regimens.… read more here.
Keywords: peroxisome proliferator; adenosine receptor; emphysema; elastase induced ... See more keywords
Late Breaking Abstract - Copper-heparin counteracts elastase-induced emphysema formation
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DOI: 10.1183/13993003.congress-2020.3344
Abstract: Emphysema is caused by a protease-antiprotease imbalance and by failing maintenance mechanisms. Repair genes are upregulated in COPD lungs, but restoration nevertheless fails. Copper (Cu) is an essential cofactor in the last step of collagen/elastic… read more here.
Keywords: heparin; copper; elastase induced; formation ... See more keywords
Nanoparticle-based targeted delivery of pentagalloyl glucose reverses elastase-induced abdominal aortic aneurysm and restores aorta to the healthy state in mice
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DOI: 10.1371/journal.pone.0227165
Abstract: Aim Abdominal aortic aneurysms (AAA) is a life-threatening weakening and expansion of the abdominal aorta due to inflammatory cell infiltration and gradual degeneration of extracellular matrix (ECM). There are no pharmacological therapies to treat AAA.… read more here.
Keywords: elastase; elastase induced; pentagalloyl glucose; abdominal aortic ... See more keywords