Effectiveness of Elbasvir/Grazoprevir in US Veterans with Chronic Hepatitis C Virus Genotype 1b Infection
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DOI: 10.1007/s40121-020-00293-7
Abstract: Introduction Real-world treatment of hepatitis C virus (HCV) infection is complicated by many factors that are controlled for in the rigorous clinical trial setting. The aim of the present study was to assess the efficacy… read more here.
Keywords: elbasvir grazoprevir; treatment; genotype infection; infection ... See more keywords
Elbasvir/Grazoprevir: A Review in Chronic HCV Genotypes 1 and 4
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DOI: 10.1007/s40265-017-0739-8
Abstract: A fixed-dose combination tablet comprising the hepatitis C virus (HCV) NS5A inhibitor elbasvir and the HCV NS3/4A protease inhibitor grazoprevir (elbasvir/grazoprevir; Zepatier™) was recently approved for the treatment of chronic HCV genotype 1 and 4… read more here.
Keywords: elbasvir grazoprevir; chronic hcv; treatment; infection ... See more keywords
Efficacy of Elbasvir/Grazoprevir in Early Chronic G1/G4 Hepatitis C infection in HIV/HCV co-infected patients with mild fibrosis.
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterologia y hepatologia"
DOI: 10.1016/j.gastrohep.2020.06.019
Abstract: BACKGROUND Acute hepatitis C virus (AHC) infection is increasingly common among HIV+ men who have sex with men (MSM). Until 2017, the guidelines recommended therapy with pegylated-interferon plus ribavirin with a mild sustained virological response… read more here.
Keywords: elbasvir grazoprevir; hepatitis infection; infection; hcv ... See more keywords
Regulatory Analysis of Effects of Hepatitis C Virus NS5A Polymorphisms on Efficacy of Elbasvir and Grazoprevir.
Sign Up to like & getrecommendations! Published in 2017 at "Gastroenterology"
DOI: 10.1053/j.gastro.2016.10.017
Abstract: BACKGROUND & AIMS Elbasvir (an NS5A inhibitor) and grazoprevir (an NS3/4A protease inhibitor) are direct-acting antiviral agents recently approved in the United States for treatment of chronic hepatitis C virus (HCV) genotype 1 and 4… read more here.
Keywords: grazoprevir; elbasvir grazoprevir; treatment; hcv genotype ... See more keywords
Safety and Efficacy of Elbasvir/Grazoprevir in Patients With Hepatitis C Virus Infection and Compensated Cirrhosis: An Integrated Analysis.
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DOI: 10.1053/j.gastro.2017.01.050
Abstract: BACKGROUND & AIMS Persons with hepatitis C virus (HCV) infection are at risk of progressive liver disease, cirrhosis, and decompensation. We analyzed the effects of the direct-acting antiviral agents elbasvir and grazoprevir in patients with… read more here.
Keywords: elbasvir grazoprevir; treatment; infection; hcv genotype ... See more keywords
Assessment of drug interaction potential between the HCV direct-acting antiviral agents elbasvir/grazoprevir and the HIV integrase inhibitors raltegravir and dolutegravir
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DOI: 10.1093/jac/dky465
Abstract: BACKGROUND Elbasvir/grazoprevir is a once-daily fixed-dose combination therapy for the treatment of chronic HCV infection, including HCV/HIV coinfection. OBJECTIVES To evaluate the pharmacokinetic interaction of elbasvir and grazoprevir with raltegravir or dolutegravir. METHODS Three open-label… read more here.
Keywords: dolutegravir; elbasvir grazoprevir; raltegravir dolutegravir;
Elbasvir/grazoprevir does not worsen renal function in patients with hepatitis C virus infection and pre‐existing renal disease
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DOI: 10.1111/hepr.12899
Abstract: Treatment options have been limited for patients with hepatitis C virus (HCV) infection and chronic kidney disease stage 4/5 (CKD 4/5). The aim of this analysis was to evaluate the impact of elbasvir/grazoprevir (EBR/GZR) on… read more here.
Keywords: elbasvir grazoprevir; patients hepatitis; infection; disease ... See more keywords
Retrospective multicentre study on the effectiveness of first-line direct-acting antivirals against hepatitis C virus genotype-1.
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DOI: 10.1111/jcpt.13624
Abstract: WHAT IS KNOWN AND OBJECTIVE In Japan, ledipasvir/sofosbuvir, elbasvir/grazoprevir and glecaprevir/pibrentasvir are recommended as first-line treatments for patients with untreated hepatitis C virus genotype 1. Although they have demonstrated a high efficacy in clinical trials,… read more here.
Keywords: response; glecaprevir pibrentasvir; ledipasvir sofosbuvir; treatment ... See more keywords
Efficacy and safety of elbasvir/grazoprevir for Japanese patients with genotype 1b chronic hepatitis C complicated by chronic kidney disease, including those undergoing hemodialysis: A post hoc analysis of a multicenter study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.14447
Abstract: This study aimed to evaluate the efficacy and safety of elbasvir/grazoprevir in genotype 1b chronic hepatitis C Japanese patients with chronic kidney disease (CKD), including those undergoing hemodialysis. read more here.
Keywords: elbasvir grazoprevir; safety elbasvir; genotype chronic; efficacy safety ... See more keywords
Real‐world effectiveness of elbasvir/grazoprevir In HCV‐infected patients in the US veterans affairs healthcare system
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DOI: 10.1111/jvh.12937
Abstract: Elbasvir/grazoprevir (EBR/GZR) is an all‐oral direct‐acting antiviral agent (DAA) with high sustained virologic response (SVR) in clinical trials. This study's primary objective was to evaluate effectiveness of EBR/GZR among HCV‐infected patients in a real‐world clinical… read more here.
Keywords: real world; ebr gzr; hcv infected; elbasvir grazoprevir ... See more keywords
Investigation of Pharmacokinetic Interactions between Doravirine and Elbasvir-Grazoprevir and Ledipasvir-Sofosbuvir
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DOI: 10.1128/aac.02491-18
Abstract: Doravirine is a non-nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. Due to the high prevalence of HIV-1 and hepatitis C virus (HCV) coinfection and coadministration of HIV-1… read more here.
Keywords: ledipasvir sofosbuvir; doravirine; elbasvir grazoprevir; grazoprevir ledipasvir ... See more keywords