Impaired Clearance From the Brain Increases the Brain Exposure to Metoclopramide in Elderly Subjects
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DOI: 10.1002/cpt.2052
Abstract: The antiemetic and gastroprokinetic drug metoclopramide is a weak substrate of the blood‐brain barrier (BBB) efflux transporter P‐gp and displays central nervous system (CNS) side effects (i.e., extrapyramidal symptoms and tardive dyskinesia) caused by dopamine… read more here.
Keywords: elderly subjects; 11c metoclopramide; clearance; brain ... See more keywords
Residual effects of low dose of suvorexant, zolpidem, and ramelteon in healthy elderly subjects: A randomized double‐blind study
Sign Up to like & getrecommendations! Published in 2022 at "Neuropsychopharmacology Reports"
DOI: 10.1002/npr2.12262
Abstract: Current hypnotic agents have next‐day residual effects. The new orexin antagonist, suvorexant, has little muscle relaxation effect on the physical and cognitive function in the following morning and daytime. In this study, the effects of… read more here.
Keywords: residual effects; zolpidem ramelteon; suvorexant zolpidem; elderly subjects ... See more keywords
GC–MS measurement of spermidine and putrescine in serum of elderly subjects: intriguing association between spermidine and homoarginine
Sign Up to like & getrecommendations! Published in 2019 at "Amino Acids"
DOI: 10.1007/s00726-019-02786-3
Abstract: Gas chromatography–mass spectrometry (GC–MS) methods were developed, validated and used to measure serum spermidine (SPD) and putrescine (PUT) in 9 seropositive Helicobacter pylori ( Hp +) and 18 seronegative Helicobacter pylori ( Hp −) subjects… read more here.
Keywords: putrescine serum; elderly subjects; spermidine; measurement spermidine ... See more keywords
Evaluation of the Pharmacokinetics and Pharmacodynamics of Prasugrel in Japanese Elderly Subjects
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DOI: 10.1007/s40261-017-0525-0
Abstract: Background and ObjectiveAn increased incidence in bleeding events has been reported in Western elderly patients receiving prasugrel. Therefore, doses in Japanese elderly subjects need to be carefully determined. We assessed the pharmacokinetic and pharmacodynamic effects… read more here.
Keywords: plasma concentration; elderly subjects; maintenance dose; japanese elderly ... See more keywords
Safety, Tolerability and Pharmacokinetics of the Serotonin 5-HT6 Receptor Antagonist, SUVN-502, in Healthy Young Adults and Elderly Subjects
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DOI: 10.1007/s40261-018-0618-4
Abstract: Background and ObjectiveSUVN-502, a selective 5-HT6 receptor antagonist, was found to be active in preclinical models of cognitive deterioration suggesting a potential role in the treatment of dementia related to Alzheimer’s disease. The objective of… read more here.
Keywords: elderly subjects; adults elderly; safety tolerability; healthy young ... See more keywords
The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation
Sign Up to like & getrecommendations! Published in 2019 at "Aging Clinical and Experimental Research"
DOI: 10.1007/s40520-019-01322-3
Abstract: Background Elderly people are exposed to an increased load of stressful events and neuro-hormonal stimulation is a key finding in metabolic syndrome and its related disorders. Aims To determine the role of cortisol in elderly… read more here.
Keywords: cortisol; elderly subjects; grade inflammation; diurnal nocturnal ... See more keywords
Interstitial Lung Disease in the Elderly
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DOI: 10.1016/j.chest.2016.11.003
Abstract: Background Despite the relationship between idiopathic pulmonary fibrosis (IPF) and advancing age, little is known about the epidemiology of interstitial lung disease (ILD) in the elderly. We describe the diagnoses, clinical characteristics, and outcomes of… read more here.
Keywords: unclassifiable ild; elderly subjects; lung disease; disease ... See more keywords
Evaluation of Dependence Among Benzodiazepines in Population of Elderly Subjects Followed in Psychiatric Service in Sfax
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DOI: 10.1016/j.eurpsy.2017.01.1114
Abstract: Introduction Benzodiazepines (BZD) are the most consumed psychotropic drugs by the elders. This prescription can lead to the dependence which is a major public health problem particularly in this population. Objectives To study the prevalence… read more here.
Keywords: subjects followed; dependence; elderly subjects; bzd dependence ... See more keywords
Analysis of the subjective postural vertical on diagonal plane in elderly subjects and left hemiparetic patients after stroke
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DOI: 10.1016/j.rehab.2018.05.493
Abstract: Introduction/Background The subjective postural vertical (SPV) in healthy subjects is robustly maintained by integrating somatosensory and vestibular information, and extremely correct on frontal and sagittal plane. It is well-known that brain injury patients indicate disturbance… read more here.
Keywords: subjective postural; elderly subjects; group; stroke patients ... See more keywords
A Breakdown of Imagined Visuomotor Transformations and Its Neural Correlates in Young Elderly Subjects
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DOI: 10.1093/cercor/bhy314
Abstract: Several studies have shown age-related changes in motor imagery (MI) in older adults and the associated compensatory brain activation patterns; most of these studies have used explicit MI tasks or implicit MI tasks focused on… read more here.
Keywords: visuomotor transformations; imagined visuomotor; elderly subjects; breakdown imagined ... See more keywords
[PP.26.20] ABPM PROFILES IN VERY ELDERLY SUBJECTS
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000523913.00688.05
Abstract: Objective: Ambulatory blood pressure monitoring (ABPM) is being increasingly used in the assessment of hypertension in all age groups, confirming the continuous relationship between blood pressure (BP) and cardiovascular (CV) risk amongst older people. Moreover,… read more here.
Keywords: elderly subjects; abpm profiles; blood pressure; profiles elderly ... See more keywords