t-BuOK-Induced, NH3·MeOH-Promoted Electrochemical C(sp3)-H Amination of Saturated Heterocycles with Sulfoximines.
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DOI: 10.1021/acs.orglett.5c02042
Abstract: The t-BuOK-induced electrochemical C(sp3)-H amination of saturated heterocycles with sulfoximines was reported. t-BuOK rather than dangerous peroxides was used as the precursor of the tert-butoxy radical, which was induced by electrochemistry; this process has not… read more here.
Keywords: amination saturated; saturated heterocycles; buok induced; sp3 amination ... See more keywords
Electrochemical α-C(sp3)-H/O-H cross-coupling of isochromans and alcohols assisted by benzoic acid.
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DOI: 10.1039/d2cc03883h
Abstract: Isochroman moieties are present in a wide variety of biologically active molecules, but converting isochromans to α-substituted derivatives under mild conditions is challenging. Herein, we report a mild, convenient protocol for synthesis of α-alkoxy isochroman… read more here.
Keywords: cross coupling; electrochemical sp3; sp3 cross; isochromans alcohols ... See more keywords
Electrochemical C(sp3)-H functionalization of ethers via hydrogen-atom transfer by means of cathodic reduction.
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DOI: 10.1039/d2cc06999g
Abstract: The chemo- and stereoselective electrochemical allylation/alkylation of ethers is presented via a C(sp3)-H activation event. The electrosynthetic protocol enables the realization of a large library of functionalized ethers (35 examples) in high yields (up to… read more here.
Keywords: electrochemical sp3; hydrogen atom; atom transfer;