Rhodium-Catalyzed C-H Alkenylation/Electrocyclization Cascade Provides Dihydropyridines That Serve as Versatile Intermediates to Diverse Nitrogen Heterocycles.
Sign Up to like & getrecommendations! Published in 2021 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.1c00027
Abstract: ConspectusNitrogen heterocycles are present in approximately 60% of drugs, with nonplanar heterocycles incorporating stereogenic centers being of considerable interest to the fields of medicinal chemistry, chemical biology, and synthetic methods development. Over the past several… read more here.
Keywords: alkenylation electrocyclization; nitrogen heterocycles; electrocyclization cascade; versatile intermediates ... See more keywords
Brønsted-Acid-Catalyzed Friedel-Crafts Reaction and Electrocyclization Cascade of Indoles with α-Functionalized Carbonyls.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00554
Abstract: Reported here is an efficient Friedel-Crafts-type reaction followed by electrocyclization cascade under an air atmosphere, employing readily available building blocks as starting materials, ethanol as a solvent, and Brønsted acid as a catalyst. On the… read more here.
Keywords: reaction; cascade; friedel crafts; nsted acid ... See more keywords