Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.
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DOI: 10.1039/c9cc04022f
Abstract: Herein, we describe the development of a novel staple with an electrophilic warhead to enable the generation of stapled peptide covalent inhibitors of the p53-MDM2 protein-protein interaction (PPI). The peptide developed showed complete and selective… read more here.
Keywords: covalent inhibitors; targeted covalent; electrophile bearing; mdm2 using ... See more keywords