Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry
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DOI: 10.1021/jacs.2c08853
Abstract: Electrophiles for covalent inhibitors that are suitable for in vivo administration are rare. While acrylamides are prevalent in FDA-approved covalent drugs, chloroacetamides are considered too reactive for such purposes. We report sulfamate-based electrophiles that maintain… read more here.
Keywords: electrophiles covalent; chemistry; ligand directed; sulfamate ... See more keywords