Electrophilic Amide Activation under Mild Conditions Using 2,2,2-Trifluoroethyl Iodonium Salt: Access to Esters and Benzoxazoles.
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DOI: 10.1021/acs.orglett.5c02352
Abstract: The amide functional group is a key chemical moiety widely found in nature yet is generally considered poorly reactive. We report an electrophilic activation strategy using 2,2,2-trifluoroethyl(mesityl)iodonium triflate under very mild conditions. This approach enables… read more here.
Keywords: amide activation; mild conditions; electrophilic amide; iodonium ... See more keywords