Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF-κB Pathways by Electrophilic/Non-Electrophilic Compounds
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01256
Abstract: The transcription factor Nrf2 coordinates a multifaceted response to various forms of stress and to inflammatory processes, maintaining a homeostatic intracellular environment. Nrf2 anti-inflammatory activity has been related to the crosstalk with the transcription factor… read more here.
Keywords: cytokine; electrophilic compounds; cytokine release; release ... See more keywords
The Potassium Efflux System Kef: Bacterial Protection against Toxic Electrophilic Compounds
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DOI: 10.3390/membranes13050465
Abstract: Kef couples the potassium efflux with proton influx in gram-negative bacteria. The resulting acidification of the cytosol efficiently prevents the killing of the bacteria by reactive electrophilic compounds. While other degradation pathways for electrophiles exist,… read more here.
Keywords: system; electrophilic compounds; domain; efflux system ... See more keywords