Synthesis of 6-azaindoles via formal electrophilic [4+1]-cyclization of 3-amino-4-methyl pyridines: new frontiers of the diversity
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DOI: 10.1039/d3qo01937c
Abstract: A scalable and efficient synthesis of the 2-trifluoromethyl-3-trifluoroacetyl-6-azaindoles from 3-amino-4-methylpyridines under treatment with TFAA was disclosed. The reaction scope and limitation towards the pyridine and electrophilic components were investigated. Activation... read more here.
Keywords: cyclization amino; electrophilic cyclization; formal electrophilic; via formal ... See more keywords