X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor.
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DOI: 10.1021/acs.jmedchem.2c01044
Abstract: Fragment-based drug discovery (FBDD) has become an established method for the identification of efficient starting points for drug discovery programs. In recent years, electrophilic fragment screening has garnered increased attention from both academia and industry… read more here.
Keywords: development; inhibitor; electrophilic fragment; fragment library ... See more keywords