Electrophilic Metal Homoenolates and Their Application in the Synthesis of Cyclopropylamines
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DOI: 10.1055/s-0036-1591536
Abstract: Since their discovery, metal homoenolates have been widely explored as carbon-based nucleophiles for the β-functionalization of carbonyl derivatives. Only recently has it been reported that metal homoenolates can react as carbonyl electrophiles. In this context,… read more here.
Keywords: electrophilic metal; metal; application synthesis; homoenolates application ... See more keywords
Allylic C–H amination cross-coupling furnishes tertiary amines by electrophilic metal catalysis
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DOI: 10.1126/science.abn8382
Abstract: Intermolecular cross-coupling of terminal olefins with secondary amines to form complex tertiary amines—a common motif in pharmaceuticals—remains a major challenge in chemical synthesis. Basic amine nucleophiles in nondirected, electrophilic metal–catalyzed aminations tend to bind to… read more here.
Keywords: amination cross; electrophilic metal; cross coupling; tertiary amines ... See more keywords