Synthesis of Trisubstituted Chromanes by Lewis-Base-Catalyzed Three-Component Electrophilic Thiofunctionalization of Cyclopropene with Phenols via a Formal [3 + 3] Annulation.
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DOI: 10.1021/acs.orglett.2c02072
Abstract: A Lewis-base-catalyzed three-component electrophilic thiofunctionalization of cyclopropene with phenol is developed to furnish various trisubstituted chromanes in high trans-diasteroselectivity. This metal-free protocol is easy to scale-up, offers a unique 2,2,3-substitution pattern, and delivers chromanes with… read more here.
Keywords: lewis base; component electrophilic; electrophilic thiofunctionalization; catalyzed three ... See more keywords