Synaptotagmin: Mechanisms of an electrostatic switch
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134834
Abstract: Synaptic transmission relies on the fast, synchronous fusion of neurotransmitter filled vesicles with the presynaptic membrane. Synaptotagmin is the Ca2+ sensor that couples the Ca2+ influx into nerve terminals following an action potential with this… read more here.
Keywords: mechanisms electrostatic; synaptotagmin mechanisms; synaptotagmin; electrostatic switch ... See more keywords
Membrane phosphatidylserine allosterically regulates the cytosolic phospholipase A2 activity via an electrostatic-switch mechanism.
Sign Up to like & getrecommendations! Published in 2022 at "Soft matter"
DOI: 10.1039/d1sm01791h
Abstract: Phospholipase A2 (PLA2) is a peripheral membrane protein that plays an essential role in many inflammatory responses. However, the activation mechanisms of PLA2 on the membrane surface have not been fully understood. Herein, we have… read more here.
Keywords: membrane; phospholipase; electrostatic switch; activity ... See more keywords