C. elegans to model autophagy-related human disorders.
Sign Up to like & getrecommendations! Published in 2020 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2020.01.007
Abstract: Autophagy is a highly conserved degradation process that clears damaged intracellular macromolecules and organelles in order to maintain cellular health. Dysfunctional autophagy is fundamentally linked to the development of various human disorders and pathologies. The… read more here.
Keywords: model autophagy; human disorders; related human; elegans model ... See more keywords
Compounds from the fruits of mangrove Sonneratia apetala: Isolation, molecular docking and antiaging effects using a Caenorhabditis elegans model.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103813
Abstract: The chemical investigation of the fruits of a mangrove Sonneratia apetala collected from the Beibu Gulf led to the isolation of four new compounds, sonneradons A-D (1-4), as well as 18 known compounds (5-22). The… read more here.
Keywords: fruits mangrove; caenorhabditis elegans; elegans model; mangrove sonneratia ... See more keywords
Sucrose stearate as a biosurfactant for development of rivastigmine containing nanostructured lipid carriers and assessment of its activity against dementia in C. elegans model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2018.11.021
Abstract: Abstract Dementia defines wide-ranging symptoms related to a decline in memory or coherent thinking. The focused endeavor of the present study was to develop and assess the efficacy of rivastigmine hydrogen tartrate (RHT) loaded nanostructured… read more here.
Keywords: elegans model; nanostructured lipid; dementia; rht nlcs ... See more keywords
Phospholipase D functional ablation has a protective effect in an Alzheimer’s disease Caenorhabditis elegans model
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21918-5
Abstract: Phospholipase D (PLD) is a key player in the modulation of multiple aspects of cell physiology and has been proposed as a therapeutic target for Alzheimer’s disease (AD). Here, we characterize a PLD mutant, pld-1,… read more here.
Keywords: protective effect; alzheimer disease; pld; caenorhabditis elegans ... See more keywords
Protective effects of baicalin in a Caenorhabditis elegans model of Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology research"
DOI: 10.1093/toxres/tfaa107
Abstract: Parkinson's disease (PD) is a common neurodegenerative disorder of the central nervous system. However, the pathogenetic mechanisms of PD are far from understood. The aim of this study was to determine the protective effect of… read more here.
Keywords: caenorhabditis elegans; elegans model; expression; parkinson disease ... See more keywords
Anti-hyperglycemic contours of Madhugrit are robustly translated in the Caenorhabditis elegans model of lipid accumulation by regulating oxidative stress and inflammatory response
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1064532
Abstract: Background The prevalence of diabetes has considerably increased in recent years. In the long run, use of dual therapy of anti-diabetic agents becomes mandatory to attain euglycemia. Also, the incidences of diabetes-related co-morbidities have warranted… read more here.
Keywords: madhugrit; oxidative stress; accumulation; caenorhabditis elegans ... See more keywords
3,3′-Diindolylmethane Supplementation Maintains Oocyte Quality by Reducing Oxidative Stress and CEP-1/p53-Mediated Regulation of Germ Cells in a Reproductively Aged Caenorhabditis elegans Model
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11050950
Abstract: In recent decades, maternal age at first birth has increased, as has the risk of infertility due to rapidly declining oocyte quality with age. Therefore, an understanding of female reproductive aging and the development of… read more here.
Keywords: supplementation; reproductively aged; quality; caenorhabditis elegans ... See more keywords
Caenorhabditis elegans as a Model to Study Manganese-Induced Neurotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12101396
Abstract: Caenorhabditis elegans (C. elegans) is a nematode present worldwide. The worm shows homology to mammalian systems and expresses approximately 40% of human disease-related genes. Since Dr. Sydney Brenner first proposed C. elegans as an advantageous… read more here.
Keywords: caenorhabditis elegans; elegans model; neurotoxicity; neurotoxicity caenorhabditis ... See more keywords
Antiobesity and Antioxidative Effect of Fermented Brown Rice Using In Vitro with In Vivo Caenorhabditis elegans Model
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13020374
Abstract: Naturally occurring phytochemicals from plants or grains are crucial in reducing various metabolic disorders. Bioactive phytonutrients are abundant in the Asian dietary staple, brown rice. This research evaluated the impact of lactic acid bacteria (LABs)… read more here.
Keywords: antioxidant antiobesity; brown rice; fermented brown; elegans model ... See more keywords
Euclea divinorum Hiern: Chemical Profiling of the Leaf Extract and Its Antioxidant Activity In Silico, In Vitro and in Caenorhabditis elegans Model
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12111031
Abstract: Euclea divinorum Hiern is a medicinal plant widely distributed in the northeast parts of South Africa. This plant has been used to treat miscarriage and to alleviate gastrointestinal problems. It can also be used externally… read more here.
Keywords: leaf extract; divinorum hiern; euclea divinorum; divinorum ... See more keywords
Caenorhabditis elegans as a Model Organism to Evaluate the Antioxidant Effects of Phytochemicals
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25143194
Abstract: The nematode Caenorhabditis elegans was introduced as a model organism in biological research by Sydney Brenner in the 1970s. Since then, it has been increasingly used for investigating processes such as ageing, oxidative stress, neurodegeneration,… read more here.
Keywords: effects phytochemicals; model organism; elegans model; caenorhabditis elegans ... See more keywords