The Toxicological Risk Assessment of Cu, Mn, and Zn as Essential Elemental Impurities in Herbal Medicinal Products with Valerian Root (Valeriana officinalis L., radix) Available in Polish Pharmacies.
Sign Up to like & getrecommendations! Published in 2021 at "Biological trace element research"
DOI: 10.1007/s12011-021-02779-y
Abstract: The toxicological risk assessment (TRA) of elemental impurities (EI) in especially herbal medicinal products (HMP) is a significant challenge for pharmaceutical industry. In Europe, very popular are traditional HMP with valerian root (Valeriana officinalis L.,… read more here.
Keywords: valerian root; polish pharmacies; officinalis radix; available polish ... See more keywords
Development and validation of an ICP‐MS method for the determination of elemental impurities in TP‐6076 active pharmaceutical ingredient (API) according to USP /
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.06.045
Abstract: HighlightsDevelopment of stabilising matrix that overcomes low spike recovery problem encountered with Os and Pd.Development of a method that allows the determination of all USP required elemental impurities (As, Cd, Hg, Pb, V, Cr, Ni,… read more here.
Keywords: validation; determination; active pharmaceutical; method ... See more keywords
ICH Q3D based elemental impurities study in liquid pharmaceutical dosage form with high daily intake – comparative analysis by ICP-OES and ICP-MS
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2020.1724136
Abstract: Abstract Guideline for Elemental Impurities-Q3D of the International Conference on Harmonisation represents a new paradigm in the control of elemental impurities (EIs) in pharmaceuticals. It changes the approach toward control of EIs from the historical… read more here.
Keywords: icp; icp oes; high daily; ich q3d ... See more keywords
Determination of arsenic, cadmium, mercury, lead and nickel as elemental impurities in atorvastatin calcium by inductively coupled mass spectrometer
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DOI: 10.1177/14690667221105835
Abstract: Atorvastatin calcium is employed as front-line treatment for cardiovascular diseases. According to the international conference on harmonization (ICH) guideline ICH Q3D, elemental impurities can come into drug products from various sources. These elemental impurities do… read more here.
Keywords: mercury lead; arsenic cadmium; cadmium mercury; elemental impurities ... See more keywords
Establishment and Validation of an ICP-MS Method for Simultaneous Measurement of 24 Elemental Impurities in Ubenimex APIs According to USP/ICH guidelines
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DOI: 10.2174/1573412916999200423103711
Abstract: To control the potential presence of heavy metals in pharmaceuticals, the United States Pharmacopeia (USP) and International Conference on Harmonization (ICH) have put forth new requirements and guidelines. USP 232 and ICH Q3D specify 24… read more here.
Keywords: icp method; impurities ubenimex; method; ubenimex apis ... See more keywords
Analysis of non-carcinogenic health risk assessment of elemental impurities in vitamin C supplements
Sign Up to like & getrecommendations! Published in 2023 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.67487.14789
Abstract: Objective(s): Elemental impurity exposure that may occur in the use of supplements has the potential to pose a risk to human health. Vitamin C supplements are among the most commonly used supplements on a daily… read more here.
Keywords: non carcinogenic; sample sample; health; vitamin supplements ... See more keywords
Toxic Elemental Impurities in Herbal Weight Loss Supplements; A Study Using ICP-OES Microwave-Assisted Digestion
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DOI: 10.3390/toxics11030272
Abstract: The tendency of using weight loss herbal preparations is continuously increasing, especially for the widespread consumption of junk food that is characterized by high calories. Weight loss herbal preparations are considered a type of food… read more here.
Keywords: icp oes; loss; herbal weight; elemental impurities ... See more keywords
A First Principles Investigation of Corrosion Chemistry of Common Elemental Impurities in Mg-Al Alloys
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DOI: 10.5006/2392
Abstract: In Mg-Al alloys, experiments show that Volta potential changes with Al concentration in eutectic α-phase and the potential is nobler around the cathodic precipitate β-phase (Mg17Al12). Other elemental impurities in the anodic matrix can also… read more here.
Keywords: principles investigation; chemistry; investigation corrosion; corrosion ... See more keywords
Determination of ICH-Q3D Elemental Impurity Leachables in Glass Vials by Inductively Coupled Plasma-Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "PDA journal of pharmaceutical science and technology"
DOI: 10.5731/pdajpst.2021.012655
Abstract: Container closure systems that are used for packaging pharmaceutical products are required to satisfy numerous safety requirements. Maximum permitted limits on the concentrations of numerous toxic elemental impurities that potentially leach from the packaging are… read more here.
Keywords: glass; elemental impurities; elemental impurity; ich q3d ... See more keywords