Elephantopinolide A-P, germacrane-type sesquiterpene lactones from Elephantopus scaber induce apoptosis, autophagy and G2/M phase arrest in hepatocellular carcinoma cells.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112362
Abstract: Chromatographic purification of Elephantopus scaber led to 16 new germacrane-type sesquiterpene lactones (1-16), named elephantopinolide A-P, along with a known analogue (17). Their structures were confirmed by comprehensive spectroscopic analyses, single-crystal X-ray diffraction, and comparison… read more here.
Keywords: elephantopus scaber; sesquiterpene lactones; germacrane type; induce apoptosis ... See more keywords
Immunomodulatory Study of Different Solvent Extract of Elephantopus scaber Linn.
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DOI: 10.1055/s-0042-124357
Abstract: The aim and objective of present study is that to provide a scientific evidence for the immunomodulatory potential of Elephantopus scaber in vivo. The immunomodulatory activity was performed in petroleum ether, solvent ether, methanol and… read more here.
Keywords: elephantopus scaber; scaber; study; immunomodulatory study ... See more keywords
Three new sesquiterpene lactones from the whole plants of Elephantopus scaber.
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DOI: 10.1080/14786419.2021.1873984
Abstract: Three new sesquiterpene lactones, named scabertopinolides H - J (1 - 3), along with four known ones, desacylisodeoxyelephantopin 2-methylbutyrate (4), iso-17,19-dihydrodeoxyelephantopin (5), scabertopinolide D (6) and (2R,6R,7R,8S)-8-tigloyloxy-1(10),4(5),11(13)-germacratrien-2,15,6,12-diolide (7) were isolated from the whole plants of Elephantopus scaber. Their structures… read more here.
Keywords: elephantopus scaber; three new; plants elephantopus; whole plants ... See more keywords
Anti-neuroinflammatory Activity of Elephantopus scaber L. via Activation of Nrf2/HO-1 Signaling and Inhibition of p38 MAPK Pathway in LPS-Induced Microglia BV-2 Cells
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00397
Abstract: Elephantopus scaber L. (family: Asteraceae) has been traditionally utilized as a folkloric medicine and scientifically shown to exhibit anti-inflammatory activities in various in vivo inflammatory models. Given the lack of study on the effect of… read more here.
Keywords: elephantopus scaber; lps induced; lps; inflammatory ... See more keywords
Scabertopin Derived from Elephantopus scaber L. Mediates Necroptosis by Inducing Reactive Oxygen Species Production in Bladder Cancer In Vitro
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DOI: 10.3390/cancers14235976
Abstract: Simple Summary Scabertopin is one of the major sesquiterpene lactones from Elephantopus scaber L. Sesquiterpene lactones are thought to have fairly strong anti-cancer efficacy. However, there has not been any research report on the efficacy… read more here.
Keywords: reactive oxygen; elephantopus scaber; scabertopin; bladder cancer ... See more keywords
Elephantopus scaber L. Polysaccharides Alleviate Heat Stress-Induced Systemic Inflammation in Mice via Modulation of Characteristic Gut Microbiota and Metabolites
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DOI: 10.3390/nu16020262
Abstract: Elephantopus scaber L. (ESL) is a Chinese herb that is used both as a food and medicine, often being added to soups in summer in south China to relieve heat stress (HS), but its exact… read more here.
Keywords: heat; gut microbiota; elephantopus scaber; heat stress ... See more keywords