Gilbert's syndrome leads to elevated bilirubin after initiation of elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis
Sign Up to like & getrecommendations! Published in 2024 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.26831
Abstract: Nine people with cystic fibrosis (pwCF) were found to have isolated elevations in serum total bilirubin after starting elexacaftor/tezacaftor/ivacaftor (ETI) that were associated with Gilbert's Syndrome. In longitudinal examination, total bilirubin levels increased substantially after… read more here.
Keywords: elexacaftor tezacaftor; elevated bilirubin; cystic fibrosis; gilbert syndrome ... See more keywords
Chronically elevated bilirubin protects from cardiac reperfusion injury in the male Gunn rat
Sign Up to like & getrecommendations! Published in 2017 at "Acta Physiologica"
DOI: 10.1111/apha.12858
Abstract: Bilirubin is associated with reduced risk of cardiovascular disease, as evidenced in conditions of mild hyperbilirubinaemia (Gilbert's Syndrome). Little is known regarding myocardial stress resistance in hyperbilirubinaemic conditions or whether life‐long exposure modifies cardiac function,… read more here.
Keywords: cardiac reperfusion; elevated bilirubin; bilirubin protects; protects cardiac ... See more keywords