Astrocyte elevated gene-1 as a novel therapeutic target in malignant gliomas and its interactions with oncogenes and tumor suppressor genes
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2020.147034
Abstract: Astrocyte elevated gene-1 (AEG-1) is an oncogene and a critical signaling molecule that has a wide variety of interactions with other oncogenes and tumor suppressor genes, leading to increasing malignant properties of malignant gliomas, such… read more here.
Keywords: interactions oncogenes; gliomas; malignant gliomas; oncogenes tumor ... See more keywords
Astrocyte elevated gene-1 (AEG-1) and the A(E)Ging HIV/AIDS-HAND
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2016.03.006
Abstract: Recent attempts to analyze human immunodeficiency virus (HIV)-1-induced gene expression changes in astrocytes uncovered a multifunctional oncogene, astrocyte elevated gene-1 (AEG-1). Our previous studies revealed that AEG-1 regulates reactive astrocytes proliferation, migration and inflammation, hallmarks… read more here.
Keywords: gene aeg; hiv; elevated gene; astrocyte elevated ... See more keywords
Astrocyte elevated gene‐1 participates in the production of pro‐inflammatory cytokines in dental pulp cells via NF‐&kgr;B signalling pathway
Sign Up to like & getrecommendations! Published in 2018 at "International Endodontic Journal"
DOI: 10.1111/iej.12921
Abstract: AIM To identify the role of astrocyte elevated gene-1 (AEG-1) and the mechanism underlying the inflammatory response in dental pulp cells. METHODOLOGY Astrocyte elevated gene-1 expression was detected at different stages of pulpitis in a… read more here.
Keywords: elevated gene; astrocyte elevated; pulp cells; dental pulp ... See more keywords
Multifunctional Role of Astrocyte Elevated Gene-1 (AEG-1) in Cancer: Focus on Drug Resistance
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DOI: 10.3390/cancers13081792
Abstract: Simple Summary Chemotherapy is a major mode of treatment for cancers. However, cancer cells adapt to survive in stressful conditions and in many cases, they are inherently resistant to chemotherapy. Additionally, after initial response to… read more here.
Keywords: chemoresistance; elevated gene; astrocyte elevated; cancer cells ... See more keywords
The Scope of Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Cancer Clinicopathology: A Review
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12020308
Abstract: Since its initial cloning in 2002, a plethora of studies in a vast number of cancer indications, has strongly established AEG-1 as a bona fide oncogene. In all types of cancer cells, overexpression and knockdown… read more here.
Keywords: aeg; scope astrocyte; elevated gene; astrocyte elevated ... See more keywords