GATA2 deficiency elevates interferon regulatory factor-8 to subvert a progenitor cell differentiation program
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DOI: 10.1182/bloodadvances.2021006182
Abstract: Key Points Elevated IRF8 in granulocyte-monocyte progenitors from Gata2 −77 enhancer mutant embryos cause macrophage-biased differentiation. Genetically ablating Irf8 reverses fetal liver hematopoiesis defects of Gata2 enhancer mutant embryos, thus establishing a GATA2-IRF8 axis. read more here.
Keywords: elevates interferon; gata2 deficiency; interferon regulatory; differentiation ... See more keywords