Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo
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DOI: 10.1038/s41467-021-23561-7
Abstract: Diseases caused by heteroplasmic mitochondrial DNA mutations have no effective treatment or cure. In recent years, DNA editing enzymes were tested as tools to eliminate mutant mtDNA in heteroplasmic cells and tissues. Mitochondrial-targeted restriction endonucleases,… read more here.
Keywords: eliminate mutant; meganuclease; mtdna; mitochondrial targeted ... See more keywords