Rejuvenation by Therapeutic Elimination of Senescent Cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.03.014
Abstract: In this issue of Cell, Baar et al. show how FOXO4 protects senescent cell viability by keeping p53 sequestered in nuclear bodies, preventing it from inducing apoptosis. Disrupting this interaction with an all-D amino acid peptide… read more here.
Keywords: cell; senescent cells; therapeutic elimination; rejuvenation therapeutic ... See more keywords
Selective elimination of senescent cells by mitochondrial targeting is regulated via ANT2
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.382
Abstract: Cellular senescence is stable cell cycle arrest limiting proliferative potential of cells. Inability of immune cells to eliminate senescent cells from the organism may lead to development of age-related diseases. We have developed several mitocans,… read more here.
Keywords: mitotam; senescent cells; elimination senescent; selective elimination ... See more keywords
Elimination of Senescent Cells: Prospects According to the Subtelomere-Telomere Theory
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297918120064
Abstract: Cell senescence is an artificially reversible condition activated by various factors and characterized by replicative senescence and typical general alteration of cell functions, including extra–cellular secretion. The number of senescent cells increases with age and… read more here.
Keywords: subtelomere telomere; cells prospects; senescent cells; elimination senescent ... See more keywords