A 30-year journey of trial and error towards a tolerogenic AIDS vaccine
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Virology"
DOI: 10.1007/s00705-018-3936-1
Abstract: Since 1985, we have tested several immunological approaches to suppressing HIV replication in HIV-infected patients and to prevent HIV acquisition in uninfected people. Here, after briefly reviewing our studies on immunosuppressive treatments and therapeutic dendritic… read more here.
Keywords: year journey; journey trial; chinese macaques; elite controllers ... See more keywords
Modulation of TCR-dependent NFAT signaling is impaired in HIV-1 Nef isolates from elite controllers.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2019.02.008
Abstract: HIV-1 Nef modulates the activation state of CD4+ T cells by altering signaling events elicited by the T cell receptor (TCR). Primary nef sequences exhibit extensive inter-individual diversity that influences their ability to downregulate CD4… read more here.
Keywords: hiv; nfat signaling; elite controllers; hiv nef ... See more keywords
Increased biomarkers of cardiovascular risk in HIV-1 viremic controllers and low persistent inflammation in elite controllers and art-suppressed individuals
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-10330-9
Abstract: HIV controllers (HICs) are models of HIV functional cure, although some studies have shown persistent inflammation and increased rates of atherosclerosis in HICs. Since immune activation/inflammation contributes to the pathogenesis of cardiovascular diseases (CVD), we… read more here.
Keywords: hiv viremic; elite controllers; viremic controllers; persistent inflammation ... See more keywords
High frequency of CD8 escape mutations in elite controllers as new obstacle for HIV cure
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2129353
Abstract: ABSTRACT Accumulation of mutations in epitopes of cytolytic-T-lymphocytes immune response (CTL) in HIV-reservoir seems to be one of the reasons for shock-and-kill strategy failure. Ten non-controller patients on successful cART (TX) and seven elite controllers… read more here.
Keywords: elite controllers; hiv; escape mutations; hiv gag ... See more keywords
How 'elite controllers' tame HIV without drugs.
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.369.6507.1045
Abstract: A tiny fraction of the 38 million HIV-infected people in the world have what seems like a superpower. Without the help of antiretroviral drugs, they keep the AIDS virus at undetectable levels in their blood,… read more here.
Keywords: tame hiv; hiv without; without drugs; hiv ... See more keywords
Variations in Trim5α and Cyclophilin A genes among HIV-1 elite controllers and non controllers in Uganda: a laboratory-based cross-sectional study
Sign Up to like & getrecommendations! Published in 2020 at "Retrovirology"
DOI: 10.1186/s12977-020-00527-z
Abstract: Tripartite Motif Containing 5 alpha (TRIM5α), a restriction factor produced ubiquitously in cells and tissues of the body plays an important role in the immune response against HIV. TRIM5α targets the HIV capsid for proteosomal… read more here.
Keywords: trim5 cyclophilin; cyclophilin genes; non controllers; among hiv ... See more keywords
High Plasma sTNF-R1 Level Is Related to Loss of Natural HIV Control in Long-Term Elite Controllers
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.858872
Abstract: Human immunodeficiency virus-1 (HIV-1) elite controllers are heterogeneous due to different immunovirological features. We aimed to identify plasma biomarkers associated with loss of spontaneous HIV-1 control in long-term elite controllers (HIV-LTECs). We performed a retrospective… read more here.
Keywords: elite controllers; hiv control; loss; ltecs ... See more keywords
Bibliometric and visualized analysis of elite controllers based on CiteSpace: landscapes, hotspots, and frontiers
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1147265
Abstract: Background A unique subset of people living with HIV, known as elite controllers, possess spontaneous and consistent control over viral replication and disease progression in the absence of antiviral intervention. In-depth research on elite controllers… read more here.
Keywords: elite controllers; analysis elite; hotspots frontiers; visualized analysis ... See more keywords
Proviral Quasispecies Diversity Is Not Associated With Virologic Breakthrough or CD4+ T Cell Loss in HIV-1 Elite Controllers
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.00673
Abstract: Elite controllers (EC) are able to control HIV-1 replication to extremely low levels ( read more here.
Keywords: diversity; hiv; elite controllers; cell ... See more keywords
Distinct Plasma Concentrations of Acyl-CoA-Binding Protein (ACBP) in HIV Progressors and Elite Controllers
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14030453
Abstract: HIV elite controllers (ECs) are characterized by the spontaneous control of viral replication, and by metabolic and autophagic profiles which favor anti-HIV CD4 and CD8 T-cell responses. Extracellular acyl coenzyme A binding protein (ACBP) acts… read more here.
Keywords: binding protein; protein acbp; elite controllers; hiv ... See more keywords