Structural modification of ellipticine derivatives with alkyl groups of varying length is influential on their effects on human DNA topoisomerase II: a combined experimental and computational study
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02472-9
Abstract: The compounds reducing tumor cell viability and disrupting DNA topoisomerase reactions have been widely used in anticancer drug development. Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is a potent intercalating agent that interferes with nucleic acid processing through interaction with… read more here.
Keywords: ellipticine derivatives; dna topoisomerase; topoisomerase; effects human ... See more keywords
Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2019.03.009
Abstract: Although ellipticine (Elli) is an efficient anticancer agent, it exerts several adverse effects. One approach to decrease the adverse effects of drugs is their encapsulation inside a suitable nanocarrier, allowing targeted delivery to tumour tissue… read more here.
Keywords: neuroblastoma; cells ellipticine; cytochrome p450; ellipticine ... See more keywords
Ellipticine inhibits the proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via the STAT3 pathway
Sign Up to like & getrecommendations! Published in 2017 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2017.1327963
Abstract: Abstract Objective: Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an alkaloid isolated from Apocyanaceae plants. This study was designed to investigate the effects of ellipticine on the proliferation and apoptosis of fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis… read more here.
Keywords: fibroblast like; like synoviocytes; stat3 pathway; proliferation ... See more keywords
Anticancer and Immunomodulatory Activities of a Novel Water-Soluble Derivative of Ellipticine
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25092130
Abstract: Cancer still remains a major public health concern around the world and the search for new potential antitumor molecules is essential for fighting the disease. This study evaluated the anticancer and immunomodulatory potential of the… read more here.
Keywords: anticancer immunomodulatory; cell line; water soluble; ell so3na ... See more keywords