Structural modification of ellipticine derivatives with alkyl groups of varying length is influential on their effects on human DNA topoisomerase II: a combined experimental and computational study
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DOI: 10.1007/s00044-019-02472-9
Abstract: The compounds reducing tumor cell viability and disrupting DNA topoisomerase reactions have been widely used in anticancer drug development. Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is a potent intercalating agent that interferes with nucleic acid processing through interaction with… read more here.
Keywords: ellipticine derivatives; dna topoisomerase; topoisomerase; effects human ... See more keywords