The interaction of enteric bacterial effectors with the host engulfment pathway control innate immune responses
Sign Up to like & getrecommendations! Published in 2021 at "Gut Microbes"
DOI: 10.1080/19490976.2021.1991776
Abstract: ABSTRACT Host engulfment protein ELMO1 generates intestinal inflammation following internalization of enteric bacteria. In Shigella, bacterial effector IpgB1 interacts with ELMO1 and promotes bacterial invasion. IpgB1 belongs to the WxxxE effector family, a motif found… read more here.
Keywords: elmo1; wxxxe motif; host engulfment; interaction ... See more keywords
ELMO1 deficiency enhances platelet function.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2018016444
Abstract: Phosphatidylinositol 3-kinase is an important signaling molecule that, once activated, leads to the generation of phosphatidylinositol (3,4,5)-trisphosphate (PIP3). We performed a proteomic screen to identify PIP3-interacting proteins in human platelets. Among these proteins, we found… read more here.
Keywords: elmo1; function elmo1; elmo1 mice; function ... See more keywords
ELMO1 Deficiency Reduces Neutrophil Chemotaxis in Murine Peritonitis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098103
Abstract: Peritoneal inflammation remains a major cause of treatment failure in patients with kidney failure who receive peritoneal dialysis. Peritoneal inflammation is characterized by an increase in neutrophil infiltration. However, the molecular mechanisms that control neutrophil… read more here.
Keywords: peritonitis; peritoneal inflammation; elmo1 deficiency; reduces neutrophil ... See more keywords