The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08579-2
Abstract: The Elongator complex catalyzes posttranscriptional tRNA modifications by attaching carboxy-methyl (cm5) moieties to uridine bases located in the wobble position. The catalytic subunit Elp3 is highly conserved and harbors two individual subdomains, a radical S-adenosyl… read more here.
Keywords: elp3; acetyltransferase; elongator; subunit elp3 ... See more keywords
Cryo-EM structure of the fully assembled Elongator complex
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1232
Abstract: Abstract Transfer RNA (tRNA) molecules are essential to decode messenger RNA codons during protein synthesis. All known tRNAs are heavily modified at multiple positions through post-transcriptional addition of chemical groups. Modifications in the tRNA anticodons… read more here.
Keywords: structure; elongator complex; structure fully; cryo ... See more keywords
MBCL-21. GERMLINE ELONGATOR MUTATIONS IN SONIC HEDGEHOG MEDULLOBLASTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.497
Abstract: Abstract BACKGROUND Our previous analysis of established cancer predisposition genes in medulloblastoma (MB) identified pathogenic germline variants in ~5% of all patients. Here, we extended our analysis to include all protein-coding genes. METHODS Case-control analysis… read more here.
Keywords: elongator; elp1; analysis; elp1 associated ... See more keywords
Elongator Is Required for Root Stem Cell Maintenance by Regulating SHORTROOT Transcription1[OPEN]
Sign Up to like & getrecommendations! Published in 2018 at "Plant Physiology"
DOI: 10.1104/pp.18.00534
Abstract: Elongator subunits associate with the pre-mRNA of SHORTROOT and recruit RNAPII to the SHR gene body, and thereby contribute to root stem cell maintenance and radial patterning. SHORTROOT (SHR) is essential for stem cell maintenance… read more here.
Keywords: stem cell; elongator; cell maintenance;
The Elongator complex-associated protein DRL1 plays a positive role in immune responses against necrotrophic fungal pathogens in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular plant pathology"
DOI: 10.1111/mpp.12516
Abstract: DEFORMED ROOT AND LEAVES1 (DRL1) is an Arabidopsis homologue of the yeast TOXIN TARGET4 (TOT4)/KILLER TOXIN-INSENSITIVE12 (KTI12) protein that is physically associated with the RNA polymerase II-interacting protein complex named Elongator. Mutations in DRL1 and… read more here.
Keywords: protein; elongator; resistance; role ... See more keywords
The Elongator complex regulates hypocotyl growth in darkness and during photomorphogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.203927
Abstract: ABSTRACT The Elongator complex (hereafter Elongator) promotes RNA polymerase II-mediated transcript elongation through epigenetic activities such as histone acetylation. Elongator regulates growth, development, immune response and sensitivity to drought and abscisic acid. We demonstrate that… read more here.
Keywords: elongator; elongation; darkness; elongator complex ... See more keywords
Aspergillus fumigatus Elongator complex subunit 3 affects hyphal growth, adhesion and virulence through wobble uridine tRNA modification
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1010976
Abstract: The eukaryotic multisubunit Elongator complex has been shown to perform multiple functions in transcriptional elongation, histone acetylation and tRNA modification. However, the Elongator complex plays different roles in different organisms, and the underlying mechanisms remain… read more here.
Keywords: growth; elongator; trna modification; elongator complex ... See more keywords
Molecular architecture of the yeast Elongator complex reveals an unexpected asymmetric subunit arrangement
Sign Up to like & getrecommendations! Published in 2017 at "EMBO reports"
DOI: 10.15252/embr.201642548
Abstract: Elongator is a ~850 kDa protein complex involved in multiple processes from transcription to tRNA modification. Conserved from yeast to humans, Elongator is assembled from two copies of six unique subunits (Elp1 to Elp6). Despite… read more here.
Keywords: elongator; asymmetric subunit; unexpected asymmetric; subunit ... See more keywords
Architecture of the yeast Elongator complex
Sign Up to like & getrecommendations! Published in 2017 at "EMBO Reports"
DOI: 10.15252/embr.201643353
Abstract: The highly conserved eukaryotic Elongator complex performs specific chemical modifications on wobble base uridines of tRNAs, which are essential for proteome stability and homeostasis. The complex is formed by six individual subunits (Elp1‐6) that are… read more here.
Keywords: elongator; architecture yeast; yeast elongator; elongator complex ... See more keywords
Elongator promotes neuritogenesis via regulation of tau stability through acly activity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1015125
Abstract: The six subunits (Elp1 to Elp6) Elongator complex promotes specific uridine modifications in tRNA’s wobble site. Moreover, this complex has been indirectly involved in the regulation of α-tubulin acetylation in microtubules (MTs) via the stabilization… read more here.
Keywords: acly activity; acetylation; tau; elongator ... See more keywords
AtELP4 a subunit of the Elongator complex in Arabidopsis, mediates cell proliferation and dorsoventral polarity during leaf morphogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1033358
Abstract: The Elongator complex in eukaryotes has conserved tRNA modification functions and contributes to various physiological processes such as transcriptional control, DNA replication and repair, and chromatin accessibility. ARABIDOPSIS ELONGATOR PROTEIN 4 (AtELP4) is one of… read more here.
Keywords: cell proliferation; atelp4; elongator; arabidopsis ... See more keywords