Covalently adaptable elastin-like protein - hyaluronic acid (ELP - HA) hybrid hydrogels with secondary thermoresponsive crosslinking for injectable stem cell delivery.
Sign Up to like & getrecommendations! Published in 2017 at "Advanced functional materials"
DOI: 10.1002/adfm.201605609
Abstract: Shear-thinning, self-healing hydrogels are promising vehicles for therapeutic cargo delivery due to their ability to be injected using minimally invasive surgical procedures. We present an injectable hydrogel using a novel combination of dynamic covalent crosslinking… read more here.
Keywords: like protein; elp; elastin like; hyaluronic acid ... See more keywords
Accelerated Engineering of ELP‐Based Materials through Hybrid Biomimetic‐De Novo Predictive Molecular Design
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202312299
Abstract: Efforts to engineer high‐performance protein‐based materials inspired by nature have mostly focused on altering naturally occurring sequences to confer the desired functionalities, whereas de novo design lags significantly behind and calls for unconventional innovative approaches.… read more here.
Keywords: accelerated engineering; elp; based materials; hybrid biomimetic ... See more keywords
Effect of amino acid composition of elastin-like polypeptide nanoparticles on nonspecific protein adsorption, macrophage cell viability and phagocytosis.
Sign Up to like & getrecommendations! Published in 2021 at "Biopolymers"
DOI: 10.1002/bip.23468
Abstract: Development of elastin-like polypeptide (ELP) biomaterials is widespread, but information critical for clinical deployment is limited, with biocompatibility studies focused on a narrow cross-section of ELP sequences. Macrophages can impair biomaterial systems by degrading or… read more here.
Keywords: elp nps; amino acid; elp; elastin like ... See more keywords
Synthesis of single‐chain antibody fragment fused to the elastin‐like polypeptide in Nicotiana benthamiana and its application in affinity precipitation of difficult to produce proteins
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28158
Abstract: Plants are economical and sustainable factories for the production of recombinant proteins. Currently, numerous proteins produced using different plant‐based systems with applications as cosmetic and tissue culture ingredients, research and diagnostic reagents, and industrial enzymes… read more here.
Keywords: elp; elastin like; single chain; chain antibody ... See more keywords
Visualization of the temperature dependent rearrangement of SynB1 elastin-like polypeptide on silica using scanning electron microscopy.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2018.07.023
Abstract: In this study, scanning electron microscopy (SEM) was used to observe the interaction between de-solvated SynB1-elastin-like polypeptide (SynB1-ELP) and silica at a temperature above ELP's lower critical solution temperature (LCST). ELP was seen to initially… read more here.
Keywords: temperature; microscopy; silica; elp ... See more keywords
Co-delivery of a growth factor and a tissue-protective molecule using elastin biopolymers accelerates wound healing in diabetic mice.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.06.043
Abstract: Growth factor therapy is a promising approach for chronic diabetic wounds, but strategies to efficiently and cost-effectively deliver active molecules to the highly proteolytic wound environment remain as major obstacles. Here, we re-engineered keratinocyte growth… read more here.
Keywords: growth factor; ara290; ara290 elp; elp ... See more keywords
Coupling a recombinant oxidase to catalase through specific noncovalent interaction to improve the oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid.
Sign Up to like & getrecommendations! Published in 2021 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2021.109895
Abstract: 5-Hydroxymethylfurfural oxidase (HMFO) can catalyze both hydroxyl and aldehyde oxidations. It catalyzes 5-hydroxymethylfurfural into 2,5-furandicarboxylic acid. However, the application of HMFO encountered two problems: the expressed HMFO in Escherichia coli. is largely in the form… read more here.
Keywords: elp hmfo; hydroxymethylfurfural furandicarboxylic; furandicarboxylic acid; elp ... See more keywords
Programmable stimuli-responsive polypeptides for biomimetic synthesis of silica nanocomposites and enzyme self-immobilization.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.05.159
Abstract: Bioinspired silicification is an attractive route for achieving unique silica nanocomposites. Herein, a novel, facile and inexpensive route for biosilica synthesis is developed using the stimuli-responsive elastin-like polypeptide (ELP). The ELP is precisely tailored to… read more here.
Keywords: immobilization; elp; stimuli responsive; self immobilization ... See more keywords
Application of elastin-like polypeptide (ELP) containing extra-cellular matrix (ECM) binding ligands in regenerative medicine.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.03.018
Abstract: Extracellular matrix (ECM) molecules play an important role in regulating molecular signaling associated with proliferation, migration, differentiation, and tissue repair. The identification of new kinds of ECM mimic biomaterials to recapitulate critical functions of biological… read more here.
Keywords: medicine; matrix ecm; elp; elastin like ... See more keywords
Systemic biopolymer-delivered vascular endothelial growth factor promotes therapeutic angiogenesis in experimental renovascular disease.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2017.09.029
Abstract: We recently developed a therapeutic biopolymer composed of an elastin-like polypeptide (ELP) fused to vascular endothelial growth factor (VEGF) and showed long-term renoprotective effects in experimental renovascular disease after a single intra-renal administration. Here, we… read more here.
Keywords: renovascular disease; vascular endothelial; endothelial growth; elp ... See more keywords
314. Maternally sequestered biologics for treatment of preeclampsia
Sign Up to like & getrecommendations! Published in 2018 at "Pregnancy Hypertension"
DOI: 10.1016/j.preghy.2018.08.363
Abstract: Introduction Preeclampsia is a hypertensive syndrome of pregnancy with few pharmacological treatment options. The risk of for adverse fetal effects is a major limitation for drug development. Our lab has developed a protein-based drug carrier… read more here.
Keywords: drug; maternally sequestered; treatment preeclampsia; elp ... See more keywords