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Published in 2017 at "Advanced functional materials"
DOI: 10.1002/adfm.201605609
Abstract: Shear-thinning, self-healing hydrogels are promising vehicles for therapeutic cargo delivery due to their ability to be injected using minimally invasive surgical procedures. We present an injectable hydrogel using a novel combination of dynamic covalent crosslinking…
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Keywords:
like protein;
elp;
elastin like;
hyaluronic acid ... See more keywords
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Published in 2021 at "Biopolymers"
DOI: 10.1002/bip.23468
Abstract: Development of elastin-like polypeptide (ELP) biomaterials is widespread, but information critical for clinical deployment is limited, with biocompatibility studies focused on a narrow cross-section of ELP sequences. Macrophages can impair biomaterial systems by degrading or…
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Keywords:
elp nps;
amino acid;
elp;
elastin like ... See more keywords
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Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28158
Abstract: Plants are economical and sustainable factories for the production of recombinant proteins. Currently, numerous proteins produced using different plant‐based systems with applications as cosmetic and tissue culture ingredients, research and diagnostic reagents, and industrial enzymes…
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Keywords:
elp;
elastin like;
single chain;
chain antibody ... See more keywords
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Published in 2018 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2018.07.023
Abstract: In this study, scanning electron microscopy (SEM) was used to observe the interaction between de-solvated SynB1-elastin-like polypeptide (SynB1-ELP) and silica at a temperature above ELP's lower critical solution temperature (LCST). ELP was seen to initially…
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Keywords:
temperature;
microscopy;
silica;
elp ... See more keywords
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Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.06.043
Abstract: Growth factor therapy is a promising approach for chronic diabetic wounds, but strategies to efficiently and cost-effectively deliver active molecules to the highly proteolytic wound environment remain as major obstacles. Here, we re-engineered keratinocyte growth…
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Keywords:
growth factor;
ara290;
ara290 elp;
elp ... See more keywords
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Published in 2021 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2021.109895
Abstract: 5-Hydroxymethylfurfural oxidase (HMFO) can catalyze both hydroxyl and aldehyde oxidations. It catalyzes 5-hydroxymethylfurfural into 2,5-furandicarboxylic acid. However, the application of HMFO encountered two problems: the expressed HMFO in Escherichia coli. is largely in the form…
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Keywords:
elp hmfo;
hydroxymethylfurfural furandicarboxylic;
furandicarboxylic acid;
elp ... See more keywords
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Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.05.159
Abstract: Bioinspired silicification is an attractive route for achieving unique silica nanocomposites. Herein, a novel, facile and inexpensive route for biosilica synthesis is developed using the stimuli-responsive elastin-like polypeptide (ELP). The ELP is precisely tailored to…
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Keywords:
immobilization;
elp;
stimuli responsive;
self immobilization ... See more keywords
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Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.03.018
Abstract: Extracellular matrix (ECM) molecules play an important role in regulating molecular signaling associated with proliferation, migration, differentiation, and tissue repair. The identification of new kinds of ECM mimic biomaterials to recapitulate critical functions of biological…
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Keywords:
medicine;
matrix ecm;
elp;
elastin like ... See more keywords
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Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2017.09.029
Abstract: We recently developed a therapeutic biopolymer composed of an elastin-like polypeptide (ELP) fused to vascular endothelial growth factor (VEGF) and showed long-term renoprotective effects in experimental renovascular disease after a single intra-renal administration. Here, we…
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Keywords:
renovascular disease;
vascular endothelial;
endothelial growth;
elp ... See more keywords
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Published in 2018 at "Pregnancy Hypertension"
DOI: 10.1016/j.preghy.2018.08.363
Abstract: Introduction Preeclampsia is a hypertensive syndrome of pregnancy with few pharmacological treatment options. The risk of for adverse fetal effects is a major limitation for drug development. Our lab has developed a protein-based drug carrier…
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Keywords:
drug;
maternally sequestered;
treatment preeclampsia;
elp ... See more keywords
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Published in 2018 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2018.08.003
Abstract: The clinical use of recombinant interferons (rIFNs) is limited by higher purification cost and quick clearance from circulation. Elastin-like polypeptides (ELPs) are a novel tag for recombinant protein purification and half-life extension. In this study,…
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Keywords:
plasma stability;
elp;
fusion;
purification ... See more keywords