Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome
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DOI: 10.7554/elife.53535
Abstract: New enzymes often evolve by gene amplification and divergence. Previous experimental studies have followed the evolutionary trajectory of an amplified gene, but have not considered mutations elsewhere in the genome when fitness is limited by… read more here.
Keywords: mutations elsewhere; link enzyme; weak link; elsewhere genome ... See more keywords