Elucidating the Determinants of Polymerase Specificity by Microfluidic-Based Deep Mutational Scanning.
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DOI: 10.1021/acssynbio.9b00104
Abstract: Engineering polymerases to synthesize artificial genetic polymers with unique backbone structures is limited by a general lack of understanding about the structural determinants that govern substrate specificity. Here, we report a high-throughput microfluidic-based approach for… read more here.
Keywords: deep mutational; microfluidic based; polymerase specificity; mutational scanning ... See more keywords