XIAP inhibitor embelin induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Toxicology"
DOI: 10.1002/tox.22450
Abstract: Embelin is an active ingredient of traditional herbal remedies for cancer and other diseases. Recently, it has been suggested that autophagy may play an important role in cancer therapy. However, little data are available regarding… read more here.
Keywords: inhibitor; squamous cell; cell death; cell ... See more keywords
Design, Synthesis, and Pharmacological Evaluation of Embelin-Aryl/alkyl Amine Hybrids as Orally Bioavailable Blood-Brain Barrier Permeable Multitargeted Agents with Therapeutic Potential in Alzheimer's Disease: Discovery of SB-1448.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00030
Abstract: The complex and multifaceted nature of Alzheimer's disease has brought about a pressing demand to develop ligands targeting multiple pathways to combat its outrageous prevalence. Embelin is a major secondary metabolite of Embelia ribes Burm… read more here.
Keywords: amine hybrids; alzheimer disease; alkyl amine; embelin aryl ... See more keywords
Embelin impairs the accumulation and activation of MDSCs in colitis-associated tumorigenesis
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2018.1498437
Abstract: ABSTRACT Myeloid-derived suppressor cells (MDSCs) are a major component of the immunosuppressive tumor microenvironment and has been recognized as a contributing factor for inflammation-related cancers. We previously showed that embelin has potent anti-inflammatory and anti-tumor… read more here.
Keywords: impairs accumulation; embelin impairs; mdscs; colitis associated ... See more keywords
Efficient Multicomponent Synthesis of Diverse Antibacterial Embelin-Privileged Structure Conjugates
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25143290
Abstract: A library of embelin derivatives has been synthesized through a multicomponent reaction from embelin (1), aldehydes and privileged structures such as 4-hydroxycoumarin, 4-hydroxy-2H-pyran-2-one and 2-naphthol, in the presence of InCl3 as catalyst. This multicomponent reaction… read more here.
Keywords: efficient multicomponent; multicomponent synthesis; diverse antibacterial; synthesis diverse ... See more keywords
Optimization of Extraction Conditions and Cytotoxic Activity of Rapanone in Comparison to Its Homologue, Embelin
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27227912
Abstract: Rapanone is a plant-derived simple alkyl-dihydroxybenzoquinone structurally close to embelin, a well-known cytotoxic agent. The pharmacological characterization of rapanone is still incomplete, and to fill the data gap, a good source for its acquisition is… read more here.
Keywords: cytotoxic activity; ic50; extraction; rapanone ... See more keywords
Pharmacological evaluation of embelin - chitosan nanoparticles as an antidiabetic agent
Sign Up to like & getrecommendations! Published in 2022 at "Indian Journal of Pharmacology"
DOI: 10.4103/ijp.ijp_47_20
Abstract: Embelin has been reported to possess variety of pharmacological activities such as androgenic antagonists, antiangiogenic, antibacterial, anticancer, anticonvulsant, antidiabetic, antidepressant, antihelmintic, antifertility, antihyperlipidemic, anti-inflammatory, antimalarial, antimitotic, antiobesity and antioxidant properties. The current research work aimed… read more here.
Keywords: embelin chitosan; body weight; chitosan nanoparticles; pharmacological evaluation ... See more keywords
In-vitro Antioxidant and Cytotoxic Activities of Silver Nanoparticles of Embelin Isolated from Embelia ribes
Sign Up to like & getrecommendations! Published in 2019 at "Research Journal of Pharmacy and Technology"
DOI: 10.5958/0974-360x.2019.00702.9
Abstract: Embelin is a key constituent of Embelia ribes, has a wide range of pharmacological effects including antioxidant and anticancer. However, the potential of embelin as a chemotherapeutic agent is limited due to its hydrophobicity. The… read more here.
Keywords: embelin; antioxidant cytotoxic; vitro antioxidant; embelin agnps ... See more keywords
Molecules of Interest – Embelin – A Review
Sign Up to like & getrecommendations! Published in 2020 at "Research Journal of Pharmacy and Technology"
DOI: 10.5958/0974-360x.2020.00618.6
Abstract: Embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone) is an alkyl substituted hydroxy quinone isolated from numerous medicinal plants and mainly from Embelia ribes. It exhibits a wide range of biological activities and also in numerous cases is accountable for the… read more here.
Keywords: interest embelin; research; embelin review; molecules interest ... See more keywords
A comprehensive insight on the biological potential of embelin and its derivatives.
Sign Up to like & getrecommendations! Published in 2021 at "Natural Product Research"
DOI: 10.6084/m9.figshare.15052126.v1
Abstract: Naturally occurring bioactive molecules are known for their diverse biological applications such as antimicrobial, anticancer, anti-inflammatory, and analgesic activities. Also, some of the natural products act as medicinal drugs. Further, bioactive cell-permeable molecule embelin has… read more here.
Keywords: biological potential; embelin derivatives; potential embelin; insight biological ... See more keywords