Embryo‐fetal developmental toxicity and toxicokinetics of loxoprofen tromethamine intravenously administered to pregnant rats
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DOI: 10.1002/bdr2.2116
Abstract: Loxoprofen tromethamine is a novel structural compound related to loxoprofen. It has been used for the treatment of pain and inflammation. However, the embryo‐fetal developmental toxicity (EFDT) of loxoprofen tromethamine has not been evaluated in… read more here.
Keywords: developmental toxicity; fetal developmental; embryo fetal; toxicokinetics loxoprofen ... See more keywords
Embryo‐fetal safety evaluation of ondansetron in rats
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DOI: 10.1002/bdr2.2154
Abstract: Ondansetron is a 5HT3 receptor antagonist, used to mitigate the effects of nausea and vomiting after chemotherapy or surgery. Since nausea and vomiting are common experiences during the first trimester of pregnancy, this antiemetic has… read more here.
Keywords: safety evaluation; ondansetron rats; embryo fetal; evaluation ondansetron ... See more keywords
Satellite rats are redundant in embryo-fetal development studies.
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DOI: 10.1016/j.reprotox.2017.06.042
Abstract: Routinely in many laboratories, satellite rats are added to embryo-fetal development (EFD) studies for pharmaceuticals to assess toxicokinetic (TK) properties, because it is assumed that collection of multiple blood samples with relatively large volumes might… read more here.
Keywords: blood sampling; satellite rats; embryo fetal; fetal development ... See more keywords
Review of embryo-fetal developmental toxicity studies performed for pharmaceuticals approved by FDA in 2016 and 2017.
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DOI: 10.1016/j.reprotox.2018.04.008
Abstract: Details of embryo-fetal development (EFD) studies were compiled for all FDA drug approvals in 2016-17. Rats and rabbits were used for 63% of small molecule (SM) drugs. The cynomolgus monkey was used for 47% of… read more here.
Keywords: cancer drugs; fetal developmental; review embryo; embryo fetal ... See more keywords
A shortened study design for embryo-fetal development studies in the minipig.
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DOI: 10.1016/j.reprotox.2018.06.009
Abstract: The minipig is accepted from scientific and regulatory perspectives for the safety evaluation of drug candidates on embryo-fetal development. The relative size and the duration of gestation (112-115 days) in the minipig is, however, considered… read more here.
Keywords: study design; fetal development; embryo fetal; shortened study ... See more keywords
A multi-institutional study benchmarking the zebrafish developmental assay for prediction of embryotoxic plasma concentrations from rat embryo-fetal development studies.
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2019.02.004
Abstract: Predicting embryotoxicity of pharmaceutical compounds or industrial chemicals is crucial for public safety. Conventional studies which monitor embryo-fetal development in rats and rabbits are costly and time consuming. Alternative assays which are simpler and less… read more here.
Keywords: plasma; plasma concentrations; embryo fetal; assay ... See more keywords
An embryo-fetal development toxicity study with dimethylaminoethyl ginkgolide B in rats and rabbits.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology research"
DOI: 10.1039/c8tx00135a
Abstract: Ginkgo biloba (a herbal product) has long been used in traditional Chinese medicine to treat cerebrovascular and cardiovascular diseases. Ginkgolide B is one of the important pharmacologically active components of Ginkgo biloba. Dimethylaminoethyl ginkgolide B… read more here.
Keywords: fetal development; dimethylaminoethyl ginkgolide; rats rabbits; embryo fetal ... See more keywords
Mephedrone as a new synthetic amphetamine induces abortion, morphological alterations and mitochondrial dysfunction in mouse embryos
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DOI: 10.1080/15569543.2020.1803358
Abstract: Abstract We have studied the embryo-fetal toxicity of mephedrone in mice during organogenesis period on gestation day (GD) 6–15 in mice during organogenesis period intraperitoneally. Our observation showed that mephedrone induces abortion, reduction in the… read more here.
Keywords: mouse; embryo fetal; induces abortion; mephedrone ... See more keywords