Brief exposure to small molecules allows induction of mouse embryonic fibroblasts into neural crest‐like precursors
Sign Up to like & getrecommendations! Published in 2017 at "Febs Letters"
DOI: 10.1002/1873-3468.12572
Abstract: In this study, we propose a novel method for inducing neuronal cells by briefly exposing them to small‐molecule cocktails in a step‐by‐step manner. Global gene expression analysis with immunohistochemical staining and calcium flux assays reveal… read more here.
Keywords: embryonic fibroblasts; brief exposure; exposure small; crest like ... See more keywords
Isolation and Neuronal Reprogramming of Mouse Embryonic Fibroblasts.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1601-7_1
Abstract: Forced expression of specific neuronal transcription factors in mouse embryonic fibroblasts (MEFs) can lead to their direct conversion into functional neurons. Direct neuronal reprogramming has become a powerful tool to characterize individual factors and molecular… read more here.
Keywords: isolation neuronal; embryonic fibroblasts; mouse embryonic; reprogramming ... See more keywords
Wuho/WDR4 deficiency inhibits cell proliferation and induces apoptosis via DNA damage in mouse embryonic fibroblasts.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2018.03.007
Abstract: Wuho known as WDR4 encodes a highly conserved WD40-repeat protein, which has known homologues of WDR4 in human and mouse. Wuho-FEN1 interaction may have a critical role in the growth and development, and in the… read more here.
Keywords: dna damage; embryonic fibroblasts; mouse embryonic; deficiency ... See more keywords
Transcriptome analysis of two structurally related flavonoids; Apigenin and Chrysin revealed hypocholesterolemic and ketogenic effects in mouse embryonic fibroblasts.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173804
Abstract: There is no known single therapeutic drug for treating hypercholesterolemia that comes with negligible systemic side effects. In the current study, using next generation RNA sequencing approach in mouse embryonic fibroblasts we discovered that two… read more here.
Keywords: embryonic fibroblasts; two structurally; chrysin; apigenin chrysin ... See more keywords
Gemini-based lipoplexes complement the mitochondrial phenotype in MFN1-Knockout mouse embryonic fibroblasts.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00449
Abstract: Mitochondria form a dynamic network of constantly dividing and fusing organelles. The balance between these antagonistic processes is crucial for normal cellular function and requires the action of specialized proteins. The mitochondrial membrane proteins Mitofusin… read more here.
Keywords: phenotype; mfn1; mfn1 knockout; embryonic fibroblasts ... See more keywords
Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214957119
Abstract: Secretory proteins and lipids are biosynthesized in the endoplasmic reticulum (ER). The "protein quality control" system (PQC) monitors glycoprotein folding and supports the elimination of terminally misfolded polypeptides. A key component of the PQC system… read more here.
Keywords: stress; selective involvement; embryonic fibroblasts; mouse embryonic ... See more keywords
17-β estradiol exerts anti-inflammatory effects through activation of Nrf2 in mouse embryonic fibroblasts
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0221650
Abstract: Several reports indicate crosstalk between the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) and estrogen, which has a protective effect in colorectal cancer (CRC). The aim of this study was to investigate the… read more here.
Keywords: anti inflammatory; embryonic fibroblasts; tnf induced; expression ... See more keywords
Necroptosis Is a Mechanism of Death in Mouse Induced Hepatocyte-Like Cells Reprogrammed from Mouse Embryonic Fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Molecules and Cells"
DOI: 10.14348/molcells.2018.2353
Abstract: Liver transplantation is recommended for patients with liver failure, but liver donors are limited. This necessitates the development of artificial livers, and hepatocytes are necessary to develop such artificial livers. Although induced hepatocyte-like cells are… read more here.
Keywords: embryonic fibroblasts; mouse induced; induced hepatocyte; hepatocyte like ... See more keywords
An Investigation of The Effect of Extracellular Vesicles Isolated from Mouse Embryonic Fibroblasts on Wound Healing in an Experimental Diabetic Mouse Model.
Sign Up to like & getrecommendations! Published in 2022 at "Anais da Academia Brasileira de Ciencias"
DOI: 10.1590/0001-3765202120201562
Abstract: This study aimed to investigate the effects of Extracellular Vesicles (EV) secreted from mouse embryonic fibroblasts EV on wound healing of full-thickness skin defect in a diabetic mouse model. The study included both in vitro… read more here.
Keywords: extracellular vesicles; isolated mouse; wound healing; embryonic fibroblasts ... See more keywords
mTORC1-Rps15 Axis Contributes to the Mechanisms Underlying Global Translation Reduction During Senescence of Mouse Embryonic Fibroblasts
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2019.00337
Abstract: The reduction of protein translation is a common feature in senescent cells and aging organisms, yet the underlying mechanisms are not fully understood. Here we show that both global mRNA translation and mammalian/mechanistic target of… read more here.
Keywords: embryonic fibroblasts; senescence; rps15 axis; translation ... See more keywords
Establishment, characterization, and validation of novel porcine embryonic fibroblasts as a potential source for genetic modification
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1059710
Abstract: Fibroblasts are the common cell type in the connective tissue-the most abundant tissue type in the body. Fibroblasts are widely used for cell culture, for the generation of induced pluripotent stem cells (iPSCs), and as… read more here.
Keywords: validation novel; porcine embryonic; embryonic fibroblasts; characterization validation ... See more keywords