Altered expression of BRG1 and histone demethylases, and aberrant H3K4 methylation in less developmentally competent embryos at the time of embryonic genome activation
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.22762
Abstract: Epigenetics is a fundamental regulator underlying many biological functions, such as development and cell differentiation. Epigenetic modifications affect key chromatin regulation, including transcription and DNA repair, which are critical for normal embryo development. In this… read more here.
Keywords: embryonic genome; methylation; brg1; genome activation ... See more keywords
Mouse and human embryonic genome activation initiate at the one-cell stage
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2025.1594995
Abstract: At the moment of their union, fertilizing gametes (sperm and oocyte) are transcriptionally silent: gene expression has to be initiated within the resulting embryo, a process termed embryonic genome activation, EGA. Until recently, EGA was… read more here.
Keywords: embryonic genome; genome activation; cell stage; one cell ... See more keywords