Combined deletions of IHH and NHEJ1 cause chondrodystrophy and embryonic lethality in the Creeper chicken
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DOI: 10.1038/s42003-020-0870-z
Abstract: The Creeper (Cp) chicken is characterized by chondrodystrophy in Cp/+ heterozygotes and embryonic lethality in Cp/Cp homozygotes. However, the genes underlying the phenotypes have not been fully known. Here, we show that a 25 kb deletion… read more here.
Keywords: chondrodystrophy; creeper; creeper chicken; chicken ... See more keywords
96 Validation of the candidate mutation responsible for embryonic lethality in Holstein haplotype 2 carriers
Sign Up to like & getrecommendations! Published in 2021 at "Reproduction, Fertility and Development"
DOI: 10.1071/rdv33n2ab96
Abstract: Holstein haplotype 2 (HH2) is embryonic lethal and carried by 1.21% of the US Holstein population. Using next-generation sequencing, we identified a high-impact frameshift mutation in intraflagellar protein 80 (IFT80) as the putative causal mutation.… read more here.
Keywords: expression; responsible embryonic; holstein haplotype; embryos ... See more keywords
Injection of an SV40 transcriptional terminator causes embryonic lethality: a possible zebrafish model for screening nonhomologous end-joining inhibitors
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DOI: 10.2147/ott.s153576
Abstract: Introduction DNA repair by the nonhomologous end joining (NHEJ) pathway promotes tumor recurrence after chemotherapy and radiotherapy. Discovery of rapid and high-throughput techniques to screen for an effective NHEJ inhibitor drug is imperative for the… read more here.
Keywords: terminator; model; sv40 terminator; embryonic lethality ... See more keywords
Maternal Gliadin Intake Reduces Oocyte Quality with Chromosomal Aberrations and Increases Embryonic Lethality through Oxidative Stress in a Caenorhabditis elegans Model
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DOI: 10.3390/nu14245403
Abstract: Oocyte quality is essential for reproductive capacity, but it rapidly declines with age. In addition to aging, maternal nutrition is a major concern in maintaining oocyte quality. Gliadin, a major component of gluten, causes gluten… read more here.
Keywords: embryonic lethality; oocyte quality; oxidative stress; quality ... See more keywords
Targeted disruption of Rab1a causes early embryonic lethality
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DOI: 10.3892/ijmm.2022.5101
Abstract: Guanosine nucleotide diphosphate (GDP) dissociation inhibitor 2 (GDI2) regulates the GDP/guanosine triphosphate (GTP) exchange reaction of Rab proteins by inhibiting the dissociation of GDP and the subsequent binding of GTP. The present study aimed to… read more here.
Keywords: rab1a; embryonic lethality; disruption rab1a; gene ... See more keywords
Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway
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DOI: 10.7554/elife.50346
Abstract: In vivo function of CDK5 and Abl enzyme substrate 2 (Cables2), belonging to the Cables protein family, is unknown. Here, we found that targeted disruption of the entire Cables2 locus (Cables2d) caused growth retardation and… read more here.
Keywords: disruption; cables2; embryonic lethality; cables2 locus ... See more keywords