Revealing the metabolic characteristics of human embryonic stem cells by genome‐scale metabolic modeling
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13255
Abstract: Embryonic stem cells (ESCs) are characterized by a dual capacity, self‐renewal and pluripotency, which can be regulated by metabolism. A better understanding of ESC metabolism and regulatory mechanisms is pivotal for research into development, ageing,… read more here.
Keywords: genome scale; metabolic characteristics; embryonic stem; stem ... See more keywords
Fine‐tuning Nanog expression heterogeneity in embryonic stem cells by regulating a Nanog transcript‐specific microRNA
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13936
Abstract: In embryonic stem cells (ESCs), the transcription factor Nanog maintains the stemness of ESCs despite exhibiting heterogeneous expression patterns under varied culture conditions. Efficient fine‐tuning of Nanog expression heterogeneity could enable ESC proliferation and differentiation… read more here.
Keywords: stem cells; expression; embryonic stem; expression heterogeneity ... See more keywords
Cell-cell adhesions in embryonic stem cells regulate the stability and transcriptional activity of β-catenin.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS letters"
DOI: 10.1002/1873-3468.14341
Abstract: E-cadherin (CDH1) is involved in maintaining cell-cell adhesions in embryonic stem cells (ESCs). However, its function in the context of cell fate decisions is largely unknown. Using mouse ESCs (mESCs), we demonstrate that E-cadherin and… read more here.
Keywords: catenin; cell adhesions; cell; cell cell ... See more keywords
Photoacoustic Imaging of Embryonic Stem Cell-Derived Cardiomyocytes in Living Hearts with Ultrasensitive Semiconducting Polymer Nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced functional materials"
DOI: 10.1002/adfm.201704939
Abstract: The last decade has seen impressive progress in human embryonic stem cell-derived cardiomyocytes (hESC-CMs) that makes them ideal tools to repair injured hearts. To achieve an optimal outcome, advanced molecular imaging methods are essential to… read more here.
Keywords: cell derived; photoacoustic imaging; stem cell; derived cardiomyocytes ... See more keywords
Embryonic Stem Cells‐Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Science"
DOI: 10.1002/advs.201801899
Abstract: Abstract Exosomes are nanosized membrane vesicles (30–100 nm) that can easily penetrate the blood–brain barrier, safely deliver therapeutic drugs, and be modified with target ligands. Embryonic stem cells (ESCs) provide abundant exosome sources for clinical… read more here.
Keywords: esc exos; embryonic stem; stem cells; cells derived ... See more keywords
Cathepsin A regulates pluripotency, proliferation and differentiation in mouse embryonic stem cells
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3554
Abstract: Mouse embryonic stem cells (mESCs) are pluripotent cells that possess the ability to self‐renew and differentiate into three germ layers. Owing to these characteristics, mESCs act as important models for stem cell research and are… read more here.
Keywords: proliferation; differentiation; mouse embryonic; embryonic stem ... See more keywords
Non‐coding RNAs: emerging regulatory factors in the derivation and differentiation of mammalian parthenogenetic embryonic stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology International"
DOI: 10.1002/cbin.10751
Abstract: Parthenogenetic embryonic stem cells (PESCs) are ESCs derived from early parthenogenetic embryos. Haploid PESCs, containing haploid DNA, originate from a single sperm or occyte, while, diploid PESCs originate from two fused occytes. Most PESC lines… read more here.
Keywords: derivation differentiation; pescs; embryonic stem; biology ... See more keywords
Diphtheria toxin-mediated transposon-driven poly (A)-trapping efficiently disrupts transcriptionally silent genes in embryonic stem cells.
Sign Up to like & getrecommendations! Published in 2020 at "Genesis"
DOI: 10.1002/dvg.23386
Abstract: Random gene trapping is the application of insertional mutagenesis techniques that are conventionally used to inactivate protein-coding genes in mouse embryonic stem (ES) cells. Transcriptionally silent genes are not effectively targeted by conventional random gene… read more here.
Keywords: vector; transcriptionally silent; embryonic stem; stem cells ... See more keywords
Purification of pluripotent embryonic stem cells using dielectrophoresis and a flow control system
Sign Up to like & getrecommendations! Published in 2022 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.202100113
Abstract: Pluripotent stem cells (PSCs) such as embryonic stem cells and induced PSCs can differentiate into all somatic cell types such as cardiomyocytes, nerve cells, and chondrocytes. However, PSCs can easily lose their pluripotency if the… read more here.
Keywords: flow control; embryonic stem; control system; pluripotency ... See more keywords
Identification, subcellular localization and functional comparison of novel Yap splicing isoforms in mouse embryonic stem cells.
Sign Up to like & getrecommendations! Published in 2021 at "IUBMB life"
DOI: 10.1002/iub.2571
Abstract: Hippo signaling pathway is involved in many biological processes including the fate decision of embryonic stem cells (ESCs). Yes-associated protein (Yap) function as a key effector of Hippo pathway, but its role in ESCs is… read more here.
Keywords: isoforms mouse; self renewal; yap; embryonic stem ... See more keywords
Mechanism of arsenite toxicity in embryonic stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3469
Abstract: Environmental arsenite exposure has been linked to cancer as well as other diseases, presenting an important and serious public health problem. Toxicity of inorganic arsenite (iAs) has been investigated using animal models and cell culture,… read more here.
Keywords: toxicity; embryonic stem; stem cells; mechanism arsenite ... See more keywords