Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii
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DOI: 10.1128/aac.02204-20
Abstract: Recently, we reported rifabutin hyperactivity against Acinetobacter baumannii. We sought to characterize potential interactions between rifabutin and colistin, the last-resort drug for carbapenem-resistant infections. Rifabutin and colistin were synergistic in vitro and in vivo, and… read more here.
Keywords: baumannii; emergence resistance; rifabutin colistin; acinetobacter baumannii ... See more keywords
Asymmetry in reproduction strategies drives evolution of resistance in biological control systems
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DOI: 10.1371/journal.pone.0207610
Abstract: The success of biological control may depend on the control agent co-evolving with its target pest species, precluding the emergence of resistance that often undermines chemical control. However, recent evidence of a decline in attack… read more here.
Keywords: emergence resistance; control; biological control; resistance ... See more keywords
Raoultella ornithinolytica: Emergence and Resistance
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DOI: 10.2147/idr.s191387
Abstract: Abstract Raoultella ornithinolytica is an encapsulated Gram-negative, oxidase-negative, catalase-positive, aerobic, non-motile rod that belongs to the Enterobacteriaceae family. This bacterium was initially classified in the genus Klebsiella as Klebsiella ornithinolytica, until the creation of the… read more here.
Keywords: raoultella; resistance raoultella; raoultella ornithinolytica; ornithinolytica emergence ... See more keywords
Genomics, Computational Biology and Drug Discovery for Mycobacterial Infections: Fighting the Emergence of Resistance
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DOI: 10.3389/fgene.2020.00965
Abstract: Tuberculosis (TB) and leprosy are mycobacterial infections caused by Mycobacterium tuberculosis and Mycobacterium leprae respectively. These diseases continue to be endemic in developing countries where the cost of new medicines presents major challenges. The situation… read more here.
Keywords: emergence resistance; drug; resistance; biology ... See more keywords
Challenging T > MIC Using Meropenem vs. Escherichia coli and Pseudomonas aeruginosa
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DOI: 10.3389/fphar.2022.840692
Abstract: Objective: For meropenem 40%T > MIC is associated with optimal killing of P. aeruginosa and E. coli. However, it is unknown how the distribution of %T > MIC through a treatment day impacts the antimicrobial… read more here.
Keywords: mic using; emergence resistance; challenging mic; aeruginosa ... See more keywords
Cefiderocol: Systematic Review of Mechanisms of Resistance, Heteroresistance and In Vivo Emergence of Resistance
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DOI: 10.3390/antibiotics11060723
Abstract: Cefiderocol appears promising, as it can overcome most β-lactam resistance mechanisms (including β-lactamases, porin mutations, and efflux pumps). Resistance is uncommon according to large multinational cohorts, including against isolates resistant to carbapenems, ceftazidime/avibactam, ceftolozane/tazobactam, and… read more here.
Keywords: review; cefiderocol; resistance; emergence resistance ... See more keywords